{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T14:08:15Z","timestamp":1782742095883,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,2,26]],"date-time":"2015-02-26T00:00:00Z","timestamp":1424908800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Diagnostic evaluation of thyroid nodules by FNA is used in the clinical management triage based on the knowledge of the rate of malignancy of each diagnostic category. The Bethesda System for Reporting Thyroid Cytopathology was published in 2007 by the National Cancer Institute (NCI). Using this classification, we studied our institution's experience in the pediatric population calculating the rate of malignancy for each diagnostic category, comparing our findings to our <jats:bold>general<\/jats:bold> patient population and that of the literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>13,312 thyroid FNAs were performed at our institution between 1998 and 2010. 282 cases were from patients under 19 years of age. We reviewed and reclassified these cases using the new NCI categories, and pursued cytology\u2010surgical follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 282 FNA cases, 20.92% (59) were classified as unsatisfactory (U), 48.22, % (136) benign (B), 2.12% (6) Atypia of undetermined significance (AUS), 14.18% (40) suspicious for follicular neoplasm (FN), 2.12% (6) suspicious for malignancy (SM) and 12.41% (35) positive for malignancy (P). The U\u2010category was further classified into nondiagnostic (ND) 12.41% (35) and cysts (C) 8.51% (24). Seventy\u2010four children had surgical follow\u2010up. The rates of histologically confirmed malignancy were 10% in U (1\/10), 0% in B (0\/17), 50% in AUS (2\/4), 39% in FN (7\/18), 100% in SM (4\/4) and 100% in P (24\/24) categories respectively. Among the U category, malignancy rate was 0% for the ND category and 25% for the C category.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>To our knowledge, this is the first study to apply the NCI categories to the pediatric population. The rate of malignancy in the U category was only seen in the specimens with cystic component. AUS and FN categories had a higher malignancy rate (50 and 39% respectively) as compared with that of the <jats:bold>general<\/jats:bold> population (15 and 30% respectively). Given that the rates of malignancy are higher for cysts and AUS, the literature recommendation to \u201cfollow\u2010up and repeat\u201d may not apply to the pediatric population. Surgery may be reasonable in these categories instead. Diagn. Cytopathol. 2015;43:598\u2010604. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23265","type":"journal-article","created":{"date-parts":[[2015,2,27]],"date-time":"2015-02-27T05:12:49Z","timestamp":1425013969000},"page":"598-604","source":"Crossref","is-referenced-by-count":37,"title":["Fine needle aspiration of thyroid nodules in the pediatric population: A 12\u2010year cyto\u2010histological correlation experience at north shore\u2010long island jewish health system"],"prefix":"10.1002","volume":"43","author":[{"given":"Seema A.","family":"Lale","sequence":"first","affiliation":[{"name":"Department of Pathology Mercy Hospital Independence Kansas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora N.","family":"Morgenstern","sequence":"additional","affiliation":[{"name":"Department of Pathology New York Hospital Queens Flushing New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sugrue","family":"Chiara","sequence":"additional","affiliation":[{"name":"Department of Pathology Long Island Jewish Medical Cente Lake Success New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Wasserman","sequence":"additional","affiliation":[{"name":"Department of Pathology Columbia University Medical Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,2,26]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjsurg.2007.12.007"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1677\/erc.1.00882"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.109609"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-010-0391-x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-200205000-00007"},{"key":"e_1_2_5_7_1","unstructured":"AACE\/AME Task Force on Thyroid nodules American Association of Clinical Endocrinologists guidelines for the diagnosis and management of thyroid nodules. 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