{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T17:24:11Z","timestamp":1789233851910,"version":"build-2803163510"},"reference-count":29,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T00:00:00Z","timestamp":1432166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>Multiple dermal cylindromas and membranous basal cell adenoma of parotid gland in a 67\u2010year\u2010old woman with Brooke\u2010Spiegler syndrome (BSS) were examined by fine\u2010needle cytology. Histology, immunochemistry, and <jats:italic>CYLD<\/jats:italic> germline mutation testing were also performed. Cytomorphology and immunochemistry of the two lesions showed basaloid neoplasms, remarkably similar, composed by proliferating epithelial cells of basal type accompanied by a smaller proportion of myoepithelial cells. <jats:italic>CYLD<\/jats:italic> gene showed a novel germline splice acceptor site mutation (c.2042\u20101G&gt;C) with skipping of the entire exon 15. The occurrence of analogous tumors, dermal cylindromas, and membranous basal cell adenoma of the parotid gland, in the same patient may result from the action of a single gene on ontogenetically similar stem cells. Therefore, patients with BSS should be offered a genetic counselling for an early and correct diagnosis. Diagn. Cytopathol. 2015;43:654\u2013658. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23275","type":"journal-article","created":{"date-parts":[[2015,5,21]],"date-time":"2015-05-21T08:08:21Z","timestamp":1432195701000},"page":"654-658","source":"Crossref","is-referenced-by-count":12,"title":["<scp>B<\/scp>rooke\u2010<scp>S<\/scp>piegler syndrome presenting multiple concurrent cutaneous and parotid gland neoplasms: Cytologic findings on fine\u2010needle sample and description of a novel mutation of the <scp>CYLD<\/scp> gene"],"prefix":"10.1002","volume":"43","author":[{"given":"Maria Gabriella","family":"Malzone","sequence":"first","affiliation":[{"name":"Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d, S.S.D. Di Citopatologia E S.C Di Anatomia Patologica Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Cipolletta","family":"Campanile","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d, S.S.D. Di Citopatologia E S.C Di Anatomia Patologica Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nunzia Simona","family":"Losito","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d, S.S.D. Di Citopatologia E S.C Di Anatomia Patologica Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Longo","sequence":"additional","affiliation":[{"name":"S.C Di Chirurgia Maxillo\u2010Facciale ORL, Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Perri","sequence":"additional","affiliation":[{"name":"Medical Oncology Unit, Presidio Ospedaliero Centrale \u201cSS Annunziata,\u201d Taranto Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Caponigro","sequence":"additional","affiliation":[{"name":"S.C. Di Oncologia Medica Testa Collo E Sarcomi, Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Concetta","family":"Schiavone","sequence":"additional","affiliation":[{"name":"S.C. Di Radioterapia, Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Ionna","sequence":"additional","affiliation":[{"name":"S.C Di Chirurgia Maxillo\u2010Facciale ORL, Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Maiello","sequence":"additional","affiliation":[{"name":"Servizio Di Anatomia, Istologia Patologica E Citopatologia, Presidio Ospedaliero Dei Pellegrini Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Martinuzzi","sequence":"additional","affiliation":[{"name":"Dipartimento Di Medicina Interna E Specialit\u00e0 Mediche Universit\u00e0 Di Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabina","family":"Nasti","sequence":"additional","affiliation":[{"name":"Dipartimento Di Medicina Interna E Specialit\u00e0 Mediche Universit\u00e0 Di Genova Genova Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerardo","family":"Botti","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d, S.S.D. Di Citopatologia E S.C Di Anatomia Patologica Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Fulciniti","sequence":"additional","affiliation":[{"name":"Istituto Nazionale Tumori \u201cFondazione G. Pascale,\u201d, S.S.D. Di Citopatologia E S.C Di Anatomia Patologica Napoli Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,5,21]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/76006"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1295-441"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90234-1"},{"key":"e_1_2_4_5_1","first-page":"85","volume-title":"Fitzpatrick's dermatology in general medicine","author":"Kaddu S","year":"2003"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197706)39:6<2460::AID-CNCR2820390624>3.0.CO;2-6"},{"key":"e_1_2_4_7_1","first-page":"909","article-title":"Multiple cutaneous cylindromas associated with parotid and submandibular gland cylindromas","volume":"125","author":"Baican A","year":"1998","journal-title":"Ann Dermatol Venereol"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996849"},{"key":"e_1_2_4_9_1","first-page":"139","article-title":"Brooke\u2010Spiegler syndrome with parotid gland involvement","volume":"14","author":"Kakagia D","year":"2004","journal-title":"Eur J Dermatol"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.21133"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970225)81:1<51::AID-CNCR11>3.0.CO;2-B"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0278-2391(97)90288-3"},{"key":"e_1_2_4_13_1","volume-title":"Collana di citopatologia agoaspirativa","author":"Fiaccavento S","year":"1997"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCP5LTQ4RVOQAIT"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880528"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2009.01259.x"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01813.x"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700218"},{"key":"e_1_2_4_19_1","first-page":"897","volume-title":"Lever's histopathology of the skin","author":"Klein W","year":"2005"},{"key":"e_1_2_4_20_1","volume-title":"Skin pathology","author":"Weedon D.","year":"2003"},{"key":"e_1_2_4_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19830701)52:1<112::AID-CNCR2820520121>3.0.CO;2-G"},{"key":"e_1_2_4_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0022-202X.2005.23688.x"},{"key":"e_1_2_4_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00012"},{"key":"e_1_2_4_24_1","first-page":"1421","article-title":"Loss of CYLD might be associated with development of salivary gland tumors","volume":"19","author":"Fukuda M","year":"2008","journal-title":"Oncol Rep"},{"key":"e_1_2_4_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1985.tb00444.x"},{"key":"e_1_2_4_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70294-C"},{"key":"e_1_2_4_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/DAD.0b013e31824e7658"},{"key":"e_1_2_4_28_1","first-page":"89","article-title":"A novel germline mutation in the CYLD gene in a slovak patient with Brooke\u2010Spiegler syndrome","volume":"49","author":"Kacerovska D","year":"2013","journal-title":"Cesk Patol"},{"key":"e_1_2_4_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01803"},{"key":"e_1_2_4_30_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.01839.x"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23275","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T14:25:07Z","timestamp":1695565507000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,5,21]]},"references-count":29,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1002\/dc.23275"],"URL":"https:\/\/doi.org\/10.1002\/dc.23275","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,5,21]]}}}