{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:21:09Z","timestamp":1761988869008},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T00:00:00Z","timestamp":1436918400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>Women \u226530 years of age with negative (\u2212) Pap tests and positive (+) HPV co\u2010test results have a higher prevalence and cumulative risk of developing high\u2010grade cervical intraepithelial neoplasia (CIN 2+). Thus, the current management in these women is to repeat co\u2010test in 12 months or immediate reflex genotyping for HPV16 or HPV 16\/18. If genotyping is not an option, timely quality assurance (QA) rescreen of such Pap tests may be a valuable alternative. All ThinPrep Pap tests (TPPT) interpreted as negative for intra epithelial lesion (NILM) or NILM with reactive cellular changes (NILM\/RCC) and a (+) high\u2010risk HPV [Hybrid Capture 2 (HC2), Qiagen, Hilden, Germany] co\u2010test result over a 45\u2010month period (10\/2009\u201006\/2013) underwent monthly QA review. The TPPT were screened by the TP Imaging System [TIS, Hologic Inc., Bedford, MA]. Twenty five thousand six hundred and seventy five (18%) NILM and NILM\/RCC TPPT of a total of 141,548 TPPT underwent HPV co\u2010test. HPV test was (+) in 2,300 (8.9%) TPPT cases. HPV (+) cases by age group were &lt;30 years, 486 (21%), and \u226530 years, 1,814 (79%). Upon QA review, 10 cases (0.4%) were reclassified, with significant findings in three cases in \u226530 years. Two cases showed high\u2010grade squamous intraepithelial lesion (HSIL) on repeat Pap, and one case showed endocervical adenocarcinoma <jats:italic>in situ<\/jats:italic> (AIS) on biopsy. Timely QA review of HPV (+) Pap (\u2212) co\u2010tests is a valuable monitor. Ninety percentage of reclassified cases were in \u226530 age group and 70% were originally signed out by using TIS 22 Field of View (FOV) only. Three reclassified cases had significant findings on follow up (F\/U). Diagn. Cytopathol. 2015;43:763\u2013769. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23303","type":"journal-article","created":{"date-parts":[[2015,7,15]],"date-time":"2015-07-15T10:03:11Z","timestamp":1436954591000},"page":"763-769","source":"Crossref","is-referenced-by-count":4,"title":["Negative computer\u2010imaged ThinPrep Pap test and positive hybrid capture2 <scp>HPV<\/scp> co\u2010testing results: A quality assurance review"],"prefix":"10.1002","volume":"43","author":[{"given":"Rema","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine New York Presbyterian Hospital, Weill Cornell Medical College New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Molina","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine New York Presbyterian Hospital, Weill Cornell Medical College New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison M.","family":"Halligan","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; 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