{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T10:40:06Z","timestamp":1696588806559},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T00:00:00Z","timestamp":1437955200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to investigate the performance of the Fournier<jats:sup>\u00ae<\/jats:sup> self\u2010sampled device in the cytological diagnosis of cervical precursor or neoplastic lesions. The colposcopy and cervical biopsy were used as the gold standard evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>This was a case\u2013control study performed at a cervical pathology outpatient clinic from January 2008 to October 2009. Samples were obtained through physician\u2010collected mode before a colposcopic evaluation. Liquid\u2010based cytology slides obtained with the device in question were stained using the <jats:italic>Papanicolaou<\/jats:italic> method and anti\u2010p16 immunocytochemistry and were analyzed by two pathologists blind to the histological and colposcopic diagnoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diagnostic performance for Fournier device using Papanicolaou technique was sensitivity 41.1% (Pathologist 1\u2014P1) and 52.9% (Pathologist 2\u2014P2) for diagnosing low\u2010grade intraepithelial lesions; for high\u2010grade lesions and cervical cancer, sensitivity was 68.7% (P1) and 75.0% (P2) and specificity was 81.8% (P1) and 73.8% (P2). When using the anti\u2010p16 immunocytochemistry, the sensitivity for diagnosing low\u2010grade intraepithelial lesions was 57.1% (P1) and 62.9% (P2), and the sensitivity was 87.5% (P1) and 93.8% (P2) for high\u2010grade lesions and cancer. The specificity was 75.0% (P1) and 54.4% (P2).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These results show that when used with \u201cblind\u201d physician\u2010collected cytology in an outpatient setting, the Fournier<jats:sup>\u00ae<\/jats:sup> device achieved a sensitivity and specificity comparable to those obtained by the Pap test traditionally collected during a speculum examination. Diagn. Cytopathol. 2015;43:802\u2013809. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23307","type":"journal-article","created":{"date-parts":[[2015,7,27]],"date-time":"2015-07-27T09:49:26Z","timestamp":1437990566000},"page":"802-809","source":"Crossref","is-referenced-by-count":0,"title":["Cervical cytological screening: Assessment of the Fournier<sup>\u00ae<\/sup> self\u2010sampling device in a cervical pathology outpatient clinic"],"prefix":"10.1002","volume":"43","author":[{"given":"Alexandre","family":"da Silva Rocha","sequence":"first","affiliation":[{"name":"Medical Sciences Post\u2010Graduation Program Universidade Federal Do Rio Grande Do Sul\/Brasil Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Guilherme Schaefer","sequence":"additional","affiliation":[{"name":"Department of Pathology Hospital De Cl\u00ednicas De Porto Alegre Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Isabel Albano Edelweiss","sequence":"additional","affiliation":[{"name":"Department of Pathology Universidade Federal Do Rio Grande Do Sul Porto Alegre\/RS Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/152460902753668466"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/jwh.1999.8.399"},{"key":"e_1_2_9_4_1","volume-title":"2010 Conferencia Municipal de Sa\u00fade do Municipio de Porto 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