{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,8,7]],"date-time":"2024-08-07T23:33:38Z","timestamp":1723073618220},"reference-count":46,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T00:00:00Z","timestamp":1436832000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>This study evaluated the effectiveness of the ThinPrep<jats:sup>\u00ae<\/jats:sup> Imaging System (TIS) and ThinPrep<jats:sup>\u00ae<\/jats:sup> Pap Stain (TPPS). A comparative analysis was conducted to determine the detection rates of atypical squamous cells, cannot exclude high\u2010grade squamous intraepithelial lesion (ASC\u2010H), the ASC:squamous intraepithelial lesion (SIL) ratio, biopsy follow\u2010up for ASC\u2010H in terms of the screening method used (manual screening [MS] vs. TIS screening [TISS]) and the staining protocol (regular Pap stain [RPS] vs. TPPS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was performed over two periods. The RPS period included manually screened slides, whereas the TPPS period included TIS\u2009+\u2009manually screened slides. All data from the study periods were compared using statistical analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The detection rate of ASC\u2010H was significantly higher during the TPPS period than during the RPS period (0.49% vs. 0.23%); this finding is in contrast to the insignificant difference between the screening method periods. The positive predictive value (PPV) of ASC\u2010H cytodiagnosis for cervical intraepithelial neoplasia of grade 2 or more severe histologies was significantly different between manually screened and TIS slides (22.10% vs. 38.55%), in contrast to an insignificant difference between RPS and TPPS periods (37.14% vs. 29.77%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Implementation of the TIS did not change the ASC\u2010H detection rates appreciably. However, the new technology improved PPV for ASC\u2010H cytodiagnosis and enabled the detection of true disease. Our laboratory statistics indicate that the TPPS is not a superior staining protocol and did not increase our diagnostic accuracy for ASC\u2010H compared with RPS. Diagn. Cytopathol. 2015;43:863\u2013869. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23311","type":"journal-article","created":{"date-parts":[[2015,7,14]],"date-time":"2015-07-14T23:06:41Z","timestamp":1436915201000},"page":"863-869","source":"Crossref","is-referenced-by-count":4,"title":["Comparative analysis of cervical cytology screening methods and staining protocols for detection rate and accurate interpretation of <scp>ASC\u2010H<\/scp>: Data from a high\u2010volume laboratory in <scp>T<\/scp>urkey"],"prefix":"10.1002","volume":"43","author":[{"given":"Aydin","family":"Ozlem","sequence":"first","affiliation":[{"name":"Acibadem University, Medical School, Department of Pathology Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ince","family":"Umit","sequence":"additional","affiliation":[{"name":"Acibadem University, Medical School, Department of Pathology Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,7,14]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20721"},{"key":"e_1_2_6_3_1","first-page":"363","article-title":"Is it now time to evaluate the true accuracy of cervical cytology screening? 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