{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:53:24Z","timestamp":1788555204473,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T00:00:00Z","timestamp":1440460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2015,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Fine\u2010needle aspiration (FNA) is routinely used to evaluate primary thyroid lesions (PTLs), however, its role in diagnosing secondary thyroid neoplasms (STNs) has not been extensively studied. The goal was to examine the clinical and cytopathologic features of STNs diagnosed on FNA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The clinico\u2010pathologic features of 28 STNs were analyzed. All PTLs, lymphomas, and locally invasive tumors were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were 28 STNs (0.18% incidence) out of 15,800 thyroid FNAs (12 males, 16 females, 32\u2009\u2212\u200985 years), all occurring metachronously (3 weeks\u221220 years, average 78.3 months) comprising 24 (85.7%) metastatic carcinomas (14 [50%] renal; 4 [14.3%] head and neck squamous cell carcinomas, 3 [10.7%] breast, and 1 [3.6%] colorectal, uterine serous carcinoma, and lung adenosquamous carcinoma, respectively), 3 sarcomas (10.7%) and 1 melanoma (3.6%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>STNs are rare and diverse tumors which may occur decades after primary malignancy. Renal carcinomas are the most common. Prior history of malignancy, high index of suspicion, and attention to key distinguishing cytologic clues are critical for accurate diagnosis. Diagn. Cytopathol. 2015;43:904\u2013911. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23331","type":"journal-article","created":{"date-parts":[[2015,8,25]],"date-time":"2015-08-25T11:02:16Z","timestamp":1440500536000},"page":"904-911","source":"Crossref","is-referenced-by-count":34,"title":["Secondary tumors involving the thyroid gland: A multi\u2010institutional analysis of 28 cases diagnosed on fine\u2010needle aspiration"],"prefix":"10.1002","volume":"43","author":[{"given":"Kim","family":"HooKim","sequence":"first","affiliation":[{"name":"Department of Pathology Louisiana State University Health Sciences Center Shreveport Los Angeles"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Gaitor","sequence":"additional","affiliation":[{"name":"Department of Biology, Georgia State University Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology Memorial Sloan Kettering Cancer Center New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle D.","family":"Reid","sequence":"additional","affiliation":[{"name":"Department of Pathology Emory University School of Medicine, Weill Cornell Medical College Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,8,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-196408000-00001"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2004.10.009"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840130306"},{"key":"e_1_2_5_5_1","first-page":"175","article-title":"Metastatic tumors in the thyroid","volume":"74","author":"Silverberg S","year":"1966","journal-title":"Pacific Med Surg"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31829d1d09"},{"key":"e_1_2_5_7_1","first-page":"2885","article-title":"Surgical treatment of intrathyroid metastases: preliminary results of a multicentric study","volume":"28","author":"Calzolari F","year":"2008","journal-title":"Anticancer Res"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970201)79:3<574::AID-CNCR21>3.0.CO;2-#"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20706"},{"key":"e_1_2_5_10_1","first-page":"37","article-title":"Metastatic tumors of the thyroid gland: A study of 79 cases in Chinese patients","volume":"122","author":"Lam KY","year":"1998","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1001\/archinte.1987.00370020129049","article-title":"Fine\u2010needle aspiration. Usefulness for diagnosis and management of metastatic carcinoma to the thyroid","volume":"147","author":"Smith SA","year":"1987","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2005.02206.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3282-1"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4266(04)95672-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2004.03.012"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/1758-3284-4-27"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000358265"},{"key":"e_1_2_5_18_1","first-page":"E7","article-title":"Malignant melanoma metastatic to the thyroid gland: A case report and review of the literature","volume":"88","author":"Kung B","year":"2009","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_5_19_1","first-page":"705","article-title":"Value of aspiration cytology of the thyroid in metastatic disease","volume":"31","author":"Chacho MS","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1998.8.149"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2007.0343"},{"key":"e_1_2_5_22_1","unstructured":"American Cancer Society. Cancer Treatment and Survivorship Facts & Figures 2012\u20102013.2012;7:15\u201316."},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02307032"},{"key":"e_1_2_5_24_1","first-page":"427","article-title":"Diagnosis of metastatic tumours to the thyroid gland by fine needle aspiration biopsy","volume":"61","author":"Bu\u0142a G","year":"2010","journal-title":"Endokrynol Pol"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326596"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/PL00013162"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196205\/06)15:3<557::AID-CNCR2820150315>3.0.CO;2-H"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(85)90167-9"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10901"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-200109000-00009"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181788516"},{"key":"e_1_2_5_32_1","first-page":"259A","volume-title":"Metastases to the Kidney: A clinicopathologic study of forty one cases with an emphasis on deceptive features. United States and Canadian Academy of Pathology","author":"Wu A","year":"2013"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.4888.607"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23331","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23331","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T18:12:33Z","timestamp":1696615953000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23331"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8,25]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2015,11]]}},"alternative-id":["10.1002\/dc.23331"],"URL":"https:\/\/doi.org\/10.1002\/dc.23331","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8,25]]}}}