{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T06:11:27Z","timestamp":1695622287538},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T00:00:00Z","timestamp":1449705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,3]]},"abstract":"<jats:p>Infection with the trematode <jats:italic>Clonorchis sinensis<\/jats:italic> is the most common human fluke infection in East Asian populations. Although this infection is associated with obstructive jaundice or choledocholithiasis, portal vein thrombosis has not been reported. Here, we report the first case of a 60\u2010year\u2010old man who had both <jats:italic>C. sinensis<\/jats:italic> infection and portal vein thrombosis with severe hyperbilirubinemia (75.4 mg\/dl). He initially presented with abdominal pain and jaundice. Computed tomography revealed gallstones, common bile duct calculus, and thrombus in the left main branch of the portal vein. A nasobiliary tube was inserted under endoscopic retrograde cholangiography. Cytology of the bile juice revealed many <jats:italic>C. sinensis<\/jats:italic> eggs. The abdominal pain and jaundice improved following choledocholithotomy and combination treatment with a chemotherapeutic agent and anti\u2010coagulant. This case suggests that inflammation around the portal vein as a result of <jats:italic>C. sinensis<\/jats:italic> infection has the potential to evoke portal vein thrombosis. Such cases should be treated with both a chemotherapeutic agent and anti\u2010coagulant therapy. In conclusion, the possibility of infection with <jats:italic>C. sinensis<\/jats:italic> should be considered in patients presenting with hyperbilirubinemia and portal vein thrombosis, particularly in East Asian populations. Diagn. Cytopathol. 2016;44:223\u2013225. \u00a9 2015 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23400","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T09:38:48Z","timestamp":1449740328000},"page":"223-225","source":"Crossref","is-referenced-by-count":4,"title":["<i>Clonorchis sinensis<\/i> ova in bile juice cytology from a patient with severe hyperbilirubinemia and portal vein thrombosis"],"prefix":"10.1002","volume":"44","author":[{"given":"Keiichi","family":"Fujiya","sequence":"first","affiliation":[{"name":"Department of Surgery Tokyo Metropolitan Health and Medical Corporation Toshima Hospital  Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Ganno","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokyo Metropolitan Health and Medical Corporation Toshima Hospital  Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Surgery Tokyo Metropolitan Health and Medical Corporation Toshima Hospital  Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ja\u2010Mun","family":"Chong","sequence":"additional","affiliation":[{"name":"Department of Pathology Tokyo Metropolitan Health and Medical Corporation Toshima Hospital  Tokyo 173\u20100015 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2015,12,10]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.2297"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32830f9818"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2010.25.7.1011"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1079\/JOH2005300"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2010.00232.x"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1477-2574.2011.00312.x"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2012.03.011"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2012.05.028"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-012-0306-0"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parint.2011.06.007"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22772"},{"key":"e_1_2_4_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0732-8893(03)00113-5"},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(09)70096-8"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23400","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23400","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:53:32Z","timestamp":1695570812000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23400"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12,10]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2016,3]]}},"alternative-id":["10.1002\/dc.23400"],"URL":"https:\/\/doi.org\/10.1002\/dc.23400","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,12,10]]}}}