{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,2]],"date-time":"2026-08-02T14:05:30Z","timestamp":1785679530077,"version":"3.56.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,3,26]],"date-time":"2016-03-26T00:00:00Z","timestamp":1458950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Matsubayashi Foundation in the National Defense Medical College, Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,6]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Recently, claudin\u20104 (CL4) immunocytochemistry was reported to be useful for differential diagnosis in effusion cytology. We wondered whether CL4 might be useful for \u201csingle\u2010shot\u201d identification of metastatic carcinoma. The purpose of this study was to evaluate the usefulness of CL4 in effusion cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 266 cases (169 metastatic carcinomas, eight malignant mesotheliomas, and 89 reactive mesothelial cells) were selected. Immunocytochemical examinations of cell\u2010block sections were performed for CL4, Ber\u2010EP4, and MOC\u201031. We used an arbitrary 4\u2010tiered scale based on both staining intensity and positive\u2010cell percentage among all target cells, and calculated a staining index score (sum of the above two scores).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In a ROC\u2010curve analysis, higher area\u2010under\u2010curve values were found for CL4 than for Ber\u2010EP4 or MOC\u201031 (0.982, 0.942, and 0.926, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Since CL4 exhibited similar or superior usefulness to Ber\u2010EP4 and MOC\u201031, it could become the first choice for the above differential diagnosis in effusion cytology. Diagn. Cytopathol. 2016;44:499\u2013504. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23476","type":"journal-article","created":{"date-parts":[[2016,3,26]],"date-time":"2016-03-26T16:58:15Z","timestamp":1459011495000},"page":"499-504","source":"Crossref","is-referenced-by-count":22,"title":["Immunocytochemical utility of claudin\u20104 versus those of Ber\u2010EP4 and MOC\u201031 in effusion cytology"],"prefix":"10.1002","volume":"44","author":[{"given":"Tomohiro","family":"Oda","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Kawaguchi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Minabe","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misaki","family":"Dokyu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiko","family":"Kumazawa","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Shimazaki","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine National Defense Medical College Hospital Tokorozawa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Takano","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology National Defense Medical College Tokorozawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Hase","sequence":"additional","affiliation":[{"name":"Department of Surgery National Defense Medical College Tokorozawa 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