{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T08:06:00Z","timestamp":1785225960206,"version":"3.55.0"},"reference-count":14,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,5,26]],"date-time":"2016-05-26T00:00:00Z","timestamp":1464220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Oxyphilic (oncocytic) parathyroid lesions are very uncommon and their cytological features are rarely described. Due to the similarities in anatomical location and indistinguishable cytomorphological features, these lesions are easily confused with neoplastic and non\u2010neoplastic thyroid lesions on fine needle aspiration (FNA). The diagnosis becomes more challenging in cases of unusual intrathyroidal location of the parathyroid lesions in the absence of clinical evidence of hyperparathyroidism, which simulate thyroid nodules clinically. We describe a case of intrathyroidal oxyphilic parathyroid carcinoma in a 66\u2010year\u2010old female, who presented with a dominant left \u201cthyroid\u201d nodule. FNA smears were cellular, comprising predominantly of oxyphilic cells arranged in papillary\u2010like architecture with occasional nuclear grooves, which was mistaken for oncocytic variant of papillary carcinoma of the thyroid. The histological diagnosis of oxyphilic parathyroid \u201cadenoma\u201d was made following total thyroidectomy. The tumor, unfortunately, recurred 7 years later with associated multiple lung metastases. When dealing with thyroid lesions comprising predominantly of oncocytic cells, one should consider oxyphilic parathyroid neoplasms as one of the differential diagnosis. In difficult equivocal cases, a panel of immunocytochemical stains (PTH, GATA3, TTF\u20101, PAX8, and thyroglobulin) can be helpful. In addition, a combination of valuable clinical, radiological, and laboratory data, including serum calcium and parathyroid hormone levels are key to arriving at an accurate cytological diagnosis. Diagn. Cytopathol. 2016;44:688\u2013692. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23493","type":"journal-article","created":{"date-parts":[[2016,5,27]],"date-time":"2016-05-27T05:03:58Z","timestamp":1464325438000},"page":"688-692","source":"Crossref","is-referenced-by-count":15,"title":["Intrathyroidal oxyphilic parathyroid carcinoma: A potential diagnostic caveat in cytology?"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4897-9927","authenticated-orcid":false,"given":"Yin Ping","family":"Wong","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noor Akmal","family":"Sharifah","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geok Chin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony James","family":"Gill","sequence":"additional","affiliation":[{"name":"Cancer Diagnosis and Pathology Group Kolling Institute of Medical Research Royal North Shore Hospital Australia and University of Sydney  Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Z.","family":"Ali","sequence":"additional","affiliation":[{"name":"Division of Cytopathology The John Hopkins Medical Institutions Baltimore MD"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9378-3"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21338"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20115"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850401)55:7<1482::AID-CNCR2820550711>3.0.CO;2-L"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199308000-00007"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200203000-00008"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199803)18:3<192::AID-DC6>3.0.CO;2-G"},{"key":"e_1_2_4_9_1","first-page":"124","volume-title":"World health organisation classification of tumours, pathology and genetics:tumour of endocrine organs","author":"Bondeson L","year":"2004"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1740"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9102-2"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/01913129109021885"},{"key":"e_1_2_4_13_1","unstructured":"CibasES.Thyroid. In:CibasES DucatmanBS editors.Cytology: Diagnostic principles and clinical correlates. 3rd ed.Philadelphia:Saunders Elsevier;2009. p259\u2013282."},{"key":"e_1_2_4_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10003"},{"key":"e_1_2_4_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-6413-3-6"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23493","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T13:03:50Z","timestamp":1695474230000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5,26]]},"references-count":14,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2016,8]]}},"alternative-id":["10.1002\/dc.23493"],"URL":"https:\/\/doi.org\/10.1002\/dc.23493","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,5,26]]}}}