{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:25:59Z","timestamp":1783488359648,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T00:00:00Z","timestamp":1465430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>No previous study has investigated the ultrasonography (US) and cytopathological features of an inflammatory pseudonodule (IFP) associated with underlying thyroiditis. This study aimed to evaluate and identify the characteristic US features of IFP in patients who underwent US\u2010guided fine\u2010needle aspiration (US\u2010FNA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From January 2012 to December 2014, 899 patients underwent US\u2010FNA for a solid thyroid nodule that was \u22655 mm in diameter, by a single radiologist. Among them, 49 nodules showed lymphocytic thyroiditis on cytological analysis. Based on cytohistopathological and follow\u2010up US results, 28 IFP cases were included. The same radiologist and a cytopathologist retrospectively analyzed all the US images and the cytology slides, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The locations of 28 IFPs were from the right lobe (<jats:italic>n<\/jats:italic>\u2009=\u200913), left lobe (<jats:italic>n<\/jats:italic>\u2009=\u200913), and isthmus (<jats:italic>n<\/jats:italic>\u2009=\u20092). The echogenicity of 28 IFPs was hypoechoic (<jats:italic>n<\/jats:italic>\u2009=\u20095) or marked hypoechoic (<jats:italic>n<\/jats:italic>\u2009=\u200923). The common US features of IFP were marked hypoechogenicity, no calcification, smooth margin, ovoid shape, and the same vascularity as adjacent parenchyma. However, no IFP cases showed calcification, spiculated margin, taller\u2010than\u2010wide shape, and central or peripheral vascularity. The common cytopathological feature of IFP was lymphocyte infiltration, but the intensity of this was variable, with mild, moderate, and severe intensity observed in 8 (28.6%), 11 (39.2%), and 9 (32.1%) of cases, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IFP rarely showed malignant US and cytopathological features, except for marked hypoechogenicity, and these findings may be helpful for US and cytopathological diagnoses. Diagn. Cytopathol. 2016;44:725\u2013730. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23516","type":"journal-article","created":{"date-parts":[[2016,6,9]],"date-time":"2016-06-09T08:24:01Z","timestamp":1465460641000},"page":"725-730","source":"Crossref","is-referenced-by-count":7,"title":["Ultrasonographic and cytopathological features of an inflammatory pseudonodule in the thyroid gland"],"prefix":"10.1002","volume":"44","author":[{"given":"Soo Jin","family":"Jung","sequence":"first","affiliation":[{"name":"Department of Pathology Busan Paik Hospital Inje University College of Medicine 614\u2010735 Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong Wook","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiology Busan Paik Hospital Inje University College of Medicine 614\u2010735 Busan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.178.3.1780687"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373050220"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2011.12.1.1"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2014.01.004"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.185.1.1523294"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.09.2413"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.7863\/jum.2012.31.11.1767"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.2214\/ajr.176.3.1760751"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21669"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ultrasmedbio.2014.02.023"},{"key":"e_1_2_5_12_1","first-page":"442","article-title":"The incidence of thyroid carcinoma in Hashimoto's thyroiditis","volume":"53","author":"Ott RA","year":"1987","journal-title":"Am Surg"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19951201)76:11<2312::AID-CNCR2820761120>3.0.CO;2-H"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.7863\/ultra.34.5.789"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23230"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/003130299105430"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23516","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23516","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T14:50:42Z","timestamp":1696603842000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23516"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,9]]},"references-count":15,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2016,9]]}},"alternative-id":["10.1002\/dc.23516"],"URL":"https:\/\/doi.org\/10.1002\/dc.23516","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,9]]}}}