{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:35:03Z","timestamp":1790825703690,"version":"4.1.0"},"reference-count":14,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T00:00:00Z","timestamp":1466467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,10]]},"abstract":"<jats:p>CIC\u2010rearranged undifferentiated small round cell sarcoma (CIC\u2010rearranged USRCS) is a recently established type of Ewing\u2010like small round cell sarcomas, characterized by CIC gene rearrangement, most commonly CIC\u2010DUX4 fusion. This report presents the second case of CIC\u2010rearranged USRCS arising primarily in the cerebrum. A 64\u2010year\u2010old otherwise healthy woman presented with a 1 \u00d7 1 cm sized hemorrhagic subcortical tumor in the left temporo\u2010parietal lobe. The tumor repeatedly recurred, and the patient underwent three surgeries, chemotherapy with doxorubicin and ifosfamide, and radiotherapy, as well as gamma knife surgery. Systemic examination revealed no other extracranial masses. Imprint cytology revealed small to moderate\u2010sized round\u2010to\u2010ovoid tumor cells with mild pleomorphism and variations in size and shape. The nuclei contained finely granular chromatin, and some had easily\u2010recognizable nucleoli. The tumor exhibited a mainly cytoplasmic pattern of CD99 immunostaining, rather than a diffuse membranous pattern. The tumor also exhibited diffuse positivity for calretinin and p16, as well as partial positivity for WT1 (nuclear and cytoplasmic staining pattern) and D2\u201040. FISH assessment showed CIC split signals. In conclusion, CIC\u2010rearranged USRCSs can occur primarily in the cerebrum. It would be impossible to diagnose them through cytology alone, but cytology would be useful to rule out other small round cell brain tumors including gliomas, lymphomas, carcinomas, and germinoma. Immunohistochemical analysis including tests for CD99, calretinin, and WT1 would help to suggest CIC\u2010rearranged USRCSs and distinguish them from Ewing sarcomas. Additionally, immunohistochemistry for p16 might be useful in the diagnosis. Diagn. Cytopathol. 2016;44:828\u2013832. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23520","type":"journal-article","created":{"date-parts":[[2016,6,21]],"date-time":"2016-06-21T07:19:20Z","timestamp":1466493560000},"page":"828-832","source":"Crossref","is-referenced-by-count":22,"title":["A case report of\n                    <i>CIC<\/i>\n                    \u2010rearranged undifferentiated small round cell sarcoma in the cerebrum"],"prefix":"10.1002","volume":"44","author":[{"given":"Mayumi","family":"Ito","sequence":"first","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Misawo","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masateru","family":"Kitajima","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Narita","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otone","family":"Endo","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Kainan Hospital 396 Minamihonden, Maegasu\u2010Cho Yatomi Aichi 498\u20108502 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,6,21]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"WHO classification of tumours of soft tissue and bone","author":"Fletcher CDM","year":"2013"},{"key":"e_1_2_5_3_1","volume-title":"Enzinger and Weiss's soft tissue tumors","author":"Goldblum JR","year":"2014"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl136"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20945"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2014.83"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000286"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000335"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000570"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000582"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.04.023"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12985"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21685"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1312-0"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.614"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23520","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23520","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T15:25:06Z","timestamp":1695482706000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6,21]]},"references-count":14,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2016,10]]}},"alternative-id":["10.1002\/dc.23520"],"URL":"https:\/\/doi.org\/10.1002\/dc.23520","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,6,21]]}}}