{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:40:52Z","timestamp":1782603652630,"version":"3.54.5"},"reference-count":11,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,7]],"date-time":"2016-07-07T00:00:00Z","timestamp":1467849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>A case of Extramammary Paget's Disease (EMPD) involving the cervix mimicking cervical carcinoma on routine cervical cytology in a 66\u2010year\u2010old woman with a history of recurrent multifocal EMPD involving the vulva, perineum, perianal area, and rectum is reported. The patient had undergone multiple excisions and reconstructions of EMPD, however, had a benign cervical smear history and reported no vaginal bleeding. The conventional papanicolaou smear was reported as concerning for carcinoma with abundant, well preserved material illustrating highly atypical cells with anisonucleosis and dense cytoplasm and focal microacini. Gross anatomical distortion from EMPD and previous surgery precluded satisfactory outpatient colposcopic assessment. Examination under anesthesia was performed and colposcopy revealed a four quadrant high grade lesion extending into the vagina with one area suspicious for malignancy on the cervix. Directed biopsies were taken and histopathology confirmed EMPD with diffuse adenocarcinoma in situ cells infiltrating skin and mucosa of all specimens. These large pale cells were seen both a singly and in clusters of nests within the mucosa. Periodic Acid Schiff staining was positive for intracytoplasmic mucin and supportive immunohistochemistry was performed with strong reactivity in atypical cells for CK7, CEA, and Cam 5.2. There was no evidence of invasive malignancy and the patient remains under clinical surveillance. Cervical EMPD is rare but should be considered in women with abnormal cervical cytology and a history of vulval EMPD. Diagn. Cytopathol. 2016;44:931\u2013934. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23530","type":"journal-article","created":{"date-parts":[[2016,7,8]],"date-time":"2016-07-08T04:12:59Z","timestamp":1467951179000},"page":"931-934","source":"Crossref","is-referenced-by-count":6,"title":["Extramammary paget's disease mimicking localized malignancy on cervical cytology"],"prefix":"10.1002","volume":"44","author":[{"given":"Georgina","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Gynaecology Oncology Chris O'Brien Lifehouse Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9405-8195","authenticated-orcid":false,"given":"Lyndal","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Tissue Pathology and Diagnostic Oncology Royal Prince Alfred Hospital Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selvan","family":"Pather","sequence":"additional","affiliation":[{"name":"Department of Gynaecology Oncology Chris O'Brien Lifehouse Camperdown New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,7,7]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2004.00438.x"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.53.10.742"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1901.tb16346.x"},{"key":"e_1_2_4_5_1","first-page":"941","article-title":"Paget's disease with extensive involvement of the female genital tract initially detected by cervical cytosmear","volume":"122","author":"Costello TJ","year":"1988","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20260"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0b013e328360df63"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/12651858.CD009245.pub2"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-011-0325-0"},{"key":"e_1_2_4_10_1","first-page":"292","article-title":"Pagetoid lesions of the vulva: A collision between malignant melanoma and Extramammary Paget Disease","volume":"27","author":"Hill SJ","year":"2008","journal-title":"Int J Gynecol Pathol"},{"key":"e_1_2_4_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1995.1044"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(90)90269-Q"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23530","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23530","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:09:05Z","timestamp":1695503345000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23530"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,7,7]]},"references-count":11,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2016,11]]}},"alternative-id":["10.1002\/dc.23530"],"URL":"https:\/\/doi.org\/10.1002\/dc.23530","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,7,7]]}}}