{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T21:40:58Z","timestamp":1695505258826},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T00:00:00Z","timestamp":1468368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,11]]},"abstract":"<jats:p>Hyaline globules and papillary fragments in cytologic samples from two intra\u2010abdominal tumors in young females are presented including the cytological features and the correlation with the histopathologic and immunohistochemical findings. In the first case a cytologic study from an ovarian mass showed papillary structures and isolated tumor cells with epithelioid morphology, irregular reniform\u2010like nuclear contour, pale or vacuolated cytoplasm, abundant hyaline globules and occasional glomeruloid structures resembling Schiller\u2010Duval bodies. Yolk sac tumor (YST) was the diagnosis on the histological slides. Tumor cells showed positivity for cytokeratin (AE1\/AE3), epithelial membrane antigen (EMA), alpha\u2010fetoprotein (AFP) and Sal\u2010like protein 4 (SALL4). In case number two the cytologic study from a liver metastasis displayed papillary and rosette\u2010like clusters composed of uniform and bland cells showing occasional long cytoplasmic tails, hyaline globules and nuclear grooves. A diagnosis of hepatic metastasis from solid pseudopapillary neoplasm of the pancreas (SPNP) was rendered from the histology. Tumor cells revealed immunoreactivity for cytokeratin (AE1\/AE3), Vimentin, Galectin\u20101 (GAL\u20101), Neuron specific\u2010enolase, CD10, progesterone and \u03b2\u2010catenin (nuclear stain). Regarding differential diagnosis, in the patient with the ovarian mass an ovarian clear cell carcinoma was considered, as well as other germ cell tumors or metastatic carcinoma, while in the patient with a liver metastasis a neuroendocrine carcinoma was taken into account. YST and SPNP share some cytological findings, including hyaline globules, papillary structures, clear cells and intercellular eosinophilic basement membrane deposits. Thus, a detailed study and careful interpretation of the cytological, histological and immunohistochemical findings may be worthwhile to avoid a potential misdiagnosis, particularly in the cytologic specimens of the ovarian and\/or intra\u2010abdominal mass, when involving young females. Diagn. Cytopathol. 2016;44:935\u2013943. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23531","type":"journal-article","created":{"date-parts":[[2016,7,13]],"date-time":"2016-07-13T05:23:06Z","timestamp":1468387386000},"page":"935-943","source":"Crossref","is-referenced-by-count":1,"title":["Hyaline globules and papillary fragments in cytologic smears from two intra\u2010abdominal tumors (ovarian and hepatic) in female patients: A diagnostic pitfall with histologic correlation"],"prefix":"10.1002","volume":"44","author":[{"given":"Isidro","family":"Machado","sequence":"first","affiliation":[{"name":"Pathology Department Instituto Valenciano De Oncolog\u00eda Valencia Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Victoria","family":"L\u00f3pez\u2010Soto","sequence":"additional","affiliation":[{"name":"Pathology Department Hospital General Docente Enrique Cabrera Ciudad Habana 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