{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T01:16:48Z","timestamp":1771550208472,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,10,7]],"date-time":"2016-10-07T00:00:00Z","timestamp":1475798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Korea University Grant","award":["K1512591"],"award-info":[{"award-number":["K1512591"]}]},{"name":"Korea Ministry of Environment (MOE)","award":["2016001360007"],"award-info":[{"award-number":["2016001360007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:p>Current ASCCP guidelines recommend repeat cytology 12 months after HPV\u2010positive results in women aged 21\u201324 years with either atypical squamous cells of undetermined significance (ASCUS) or a low\u2010grade squamous intraepithelial lesion (LSIL). The purpose of this study was to validate an algorithm in such women with ASCUS or LSIL.<\/jats:p><jats:p>A multicenter cross\u2010sectional study was carried out at three academic hospitals involving 40,847 Korean women who underwent cervical cancer screening with cytology and HPV testing with or without subsequent colposcopic biopsies between January 2007 and December 2013.<\/jats:p><jats:p>Among a total of 3,193 women with available histopathology data, 762 women with ASCUS and 758 with LSIL were HPV\u2010positive. Among HPV\u2010positive women with ASCUS, 38.5% of women aged 21\u201324 years had \u2265CIN2, compared to 20.8% of women aged 30\u201365 years and 21.1% of the total women. Among HPV\u2010positive women with LSIL, 25.8% aged 21\u201324 years had \u2265CIN2, compared to 21.2% of women aged 30\u201365 years and 21.9% of the total women. In HPV\u2010positive women with ASCUS\/LSIL aged less than 25 years, the prevalence of \u2265CIN2 lesions was 34.5%, which was significantly higher than that (21.0%) in women aged \u226525 years.<\/jats:p><jats:p>The risk of \u2265CIN2 lesions in HPV\u2010positive Korean women aged 21\u201324 years with ASCUS or LSIL was not lower than that in older women. Colposcopic examination should be considered for management of HPV\u2010positive young women with ASCUS or LSIL. Diagn. Cytopathol. 2016;44:959\u2013963. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23533","type":"journal-article","created":{"date-parts":[[2016,10,13]],"date-time":"2016-10-13T03:57:44Z","timestamp":1476331064000},"page":"959-963","source":"Crossref","is-referenced-by-count":8,"title":["Management of atypical squamous cells of undetermined significance or low\u2010grade squamous intraepithelial lesions of the uterine cervix with human papilloma virus infection among young women aged less than 25 years"],"prefix":"10.1002","volume":"44","author":[{"given":"Ki\u2010Jin","family":"Ryu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanghoon","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyung\u2010Jin","family":"Min","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin Hwa","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Yun","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nak Woo","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Korea University Medical Center, Korea University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,7]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers6042072"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/CA.2007.0010"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3802\/jgo.2014.25.3.174"},{"key":"e_1_2_5_5_1","unstructured":"The Korea Central Cancer Registry National Cancer Center. 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