{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:09:18Z","timestamp":1754600958346},"reference-count":22,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T00:00:00Z","timestamp":1471305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2016,12]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Current cervical cancer screening guidelines recommend a 1\u2010year follow\u2010up period for patients with a postmenopausal low\u2010grade squamous intraepithelial lesion (LSIL) who are test negative for high\u2010risk human papillomavirus (HrHPV). The aim of this study was to assess whether such patients had an increased immediate risk of high\u2010grade squamous intraepithelial lesion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We assessed 54 HrHPV\u2010negative women with postmenopausal LSIL in the Department of Obstetrics and Gynecology of our hospital between 2012 and 2013. All patients underwent liquid\u2010based cytology and reflex HrHPV testing (for human papillomavirus [HPV] types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66, and 68). Colposcopic examination and guided biopsy were performed by the same gynecologist (MO).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The average age of the patients was 53.1\u2009\u00b1\u20093.2 years. There were 33 patients (61%) with cervical intraepithelial neoplasia (CIN) grade 1 and 21 who were non\u2010dysplastic. None of the patients was positive for CIN 2 or any other lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>If the HPV test is negative, repeat cytology after 12 months is recommended by the American Society for Colposcopy and Cervical Pathology for cases of HrHPV\u2010negative postmenopausal LSIL. We recommend reflex HPV testing as the best choice for patients who test positive for postmenopausal LSIL by Pap smear, in line with the literature. Diagn. Cytopathol. 2016;44:969\u2013974. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23556","type":"journal-article","created":{"date-parts":[[2016,8,16]],"date-time":"2016-08-16T11:12:43Z","timestamp":1471345963000},"page":"969-974","source":"Crossref","is-referenced-by-count":4,"title":["Risk of HSIL (CIN 2\u20133) on colposcopic biopsy is minimal in postmenopausal women with LSIL on cytology and a negative HRHPV test"],"prefix":"10.1002","volume":"44","author":[{"given":"Mustafa","family":"Ozturk","sequence":"first","affiliation":[{"name":"Obstetrics and Gynaecology Department Etimesgut Military Hospital Etimesgut Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haldun","family":"Umudum","sequence":"additional","affiliation":[{"name":"Department of Chair of Pathology Dr. R\u0131dvan Ege Hospital and Ufuk University School of Medicine Ankara 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Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcfit Cemal","family":"Yenen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology Gulhane Military Medical Academy and Medical School Etlik Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,8,16]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.5.397"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.5.2069"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_6_5_1","first-page":"253","article-title":"Prevalence of high grade squamous intraepithelial lesion (HSIL) and invasive cervical cancer in patients with low grade squamous intraepithelial lesion (LSIL) at cervical Pap smear","volume":"9","author":"Khuakoonratt N","year":"2008","journal-title":"Asian Pac J Cancer 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