{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T09:32:21Z","timestamp":1776331941733,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T00:00:00Z","timestamp":1477094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,2]]},"abstract":"<jats:p>Renal cell carcinoma metastases to pancreas, thyroid, and contralateral adrenal gland are decidedly uncommon. Clear cell renal cell carcinoma (CCRCC) is the most frequent subtype. Cytology diagnosis may be challenging. A 74\u2010year\u2010old male with remote history of vocal cord malignancy and hypertension presented with abdominal pain. Computed tomography (CT) revealed 8.4 cm left renal mass highly suspicious for renal cell carcinoma, a 1.8 cm mass within vessels near left adrenal and a 2.5 cm mass in pancreatic tail. Right pulmonary middle lobe showed two small nodules. Metastatic CCRCC was diagnosed on preoperative transgastric, endoscopic ultrasound guided fine\u2010needle aspiration cytology of pancreatic tail mass. Left radical nephrectomy and distal pancreatectomy and splenectomy confirmed CCRCC (pT3bNxM1), with metastases in adrenal and pancreatic tail. The 3p deletion identification in pancreatic tumor suggested CCRCC origin. Follow\u2010up positron emission tomography\u2010CT (PET\u2010CT) scan revealed left thyroid lower pole mass. Thyroid ultrasound showed three clustered 6 mm nodules in left mid pole. Ultrasound\u2010guided fine needle aspiration (US\u2010FNA) biopsies, 4\u2010month post\u2010nephrectomy, were consistent with metastatic renal cell carcinoma in lower, and atypia of undetermined significance in mid poles respectively. Left lobectomy and isthmus and pyramidal lobe resections confirmed metastatic renal cell carcinoma. One year post\u2010radical nephrectomy, contralateral adrenal lesion noted on PET\u2010CT was interpreted as metastatic CCRCC on CT\u2010guided core biopsy with touch imprints. Rapid on\u2010site evaluation was implemented, and immunoprofile typical of CCRCC substantiated cytomorphology at all three sites. Previously reported cases of renal cell carcinoma metastases to organs as in the described case are reviewed as well. Diagn. Cytopathol. 2017;45:161\u2013167. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23619","type":"journal-article","created":{"date-parts":[[2016,10,22]],"date-time":"2016-10-22T07:16:48Z","timestamp":1477120608000},"page":"161-167","source":"Crossref","is-referenced-by-count":14,"title":["Cytology diagnosis of metastatic clear cell renal cell carcinoma, synchronous to pancreas, and metachronous to thyroid and contralateral adrenal: Report of a case and literature review"],"prefix":"10.1002","volume":"45","author":[{"given":"Aqiba","family":"Bokhari","sequence":"first","affiliation":[{"name":"Division of Cytopathology Department of Pathology and Cell Biology New York Presbyterian\u2010Columbia University Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patricia G.","family":"Tiscornia\u2010Wasserman","sequence":"additional","affiliation":[{"name":"Division of Cytopathology Department of Pathology and Cell Biology New York Presbyterian\u2010Columbia University Medical Center New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,10,22]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.2915"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.14.8.1040"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3722"},{"key":"e_1_2_5_5_1","first-page":"185","article-title":"Renal cell carcinoma metastases to the pancreas and the thyroid gland 19 years after the primary tumour","volume":"10","author":"Wolf S","year":"2015","journal-title":"Prz Gastroenterol"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23004"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-2042.2008.02182.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21117"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31829d1d09"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1159\/000351299"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31826b3acf"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21564"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000352006"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.79779"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21541"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23331"},{"key":"e_1_2_5_17_1","first-page":"512","article-title":"Adrenal metastases of renal\u2010cell carcinoma 19 years after nephrectomy. 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