{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T11:29:33Z","timestamp":1788780573103,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T00:00:00Z","timestamp":1487894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>Langerhans cell sarcoma (LCS) and quintuple cancers are extremely rare. In this report, a case of quintuple cancers including LCS was described. An 80\u2010year\u2010old man had squamous cell carcinoma of the nasal skin, colon and rectum adenocarcinomas, and T\u2010cell\/histiocyte\u2010rich large B\u2010cell lymphoma. As swelling of multiple submental lymph nodes was observed, fine\u2010needle aspiration was carried out. Many large cells with high\u2010grade nuclear atypia and abundant cytoplasm were observed. Lymphocytes and eosinophils were observed in the background. Although a malignant tumor was suspected, a definite diagnosis could not be made. In a biopsy sample, the tumor cells were positive for vimentin, CD68, S\u2010100, CD1a, and CD163 and negative for epithelial, lymphocyte, and melanoma markers in immunohistochemistry. A diagnosis of LCS was made from the immunohistochemical findings and high mitotic rate with atypical forms. The patient died about 2 months after the first medical examination. Metastasis of LCS was confirmed in many organs by autopsy. LCS has a poor prognosis. In cases with the above\u2010described cytological findings, LCS should be added to the list of differential diagnosis. The cytological findings presented here may be useful for determining appropriate clinical management such as staging of the disease and follow\u2010up of the neoplasm. Diagn. Cytopathol. 2017;45:441\u2013445. \u00a9 2017 The Authors Diagnostic Cytopathology Published by Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23628","type":"journal-article","created":{"date-parts":[[2017,2,24]],"date-time":"2017-02-24T14:58:08Z","timestamp":1487948288000},"page":"441-445","source":"Crossref","is-referenced-by-count":8,"title":["Cytological findings of langerhans cell sarcoma in a case of quintuple cancer"],"prefix":"10.1002","volume":"45","author":[{"given":"Satomi","family":"Tabata","sequence":"first","affiliation":[{"name":"Department of Pathology Kushiro City General Hospital Syunkodai 1\u201012 Kushiro 085\u20100822 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Murata","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University, School of medicine South\u20101, West\u201017, Chuo\u2010ku Sapporo 060\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Takasawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University, School of medicine South\u20101, West\u201017, Chuo\u2010ku Sapporo 060\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hokkaido University Graduate School of Medicine Kita\u201015, Nishi\u20107, Kita\u2010ku Sapporo 060\u20108638 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ogasawara","sequence":"additional","affiliation":[{"name":"Department of Pathology Kushiro City General Hospital Syunkodai 1\u201012 Kushiro 085\u20100822 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Koseki","sequence":"additional","affiliation":[{"name":"Department of Pathology Kushiro City General Hospital Syunkodai 1\u201012 Kushiro 085\u20100822 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuhiko","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kushiro City General Hospital Syunkodai 1\u201012 Kushiro 085\u20100822 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Segawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University Hospital South\u20101, West\u201016, Chuo\u2010ku Sapporo 060\u20108543 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rena","family":"Morita","sequence":"additional","affiliation":[{"name":"Department of Pathology Kushiro City General Hospital Syunkodai 1\u201012 Kushiro 085\u20100822 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Surgical Pathology Sapporo Medical University Hospital South\u20101, West\u201016, Chuo\u2010ku Sapporo 060\u20108543 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Sawada","sequence":"additional","affiliation":[{"name":"Department of Pathology Sapporo Medical University, School of medicine South\u20101, West\u201017, Chuo\u2010ku Sapporo 060\u20108556 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,2,24]]},"reference":[{"key":"e_1_2_4_2_1","first-page":"358","volume-title":"WHO classification of tumors of the hematopoietic and lymphoid tissues","author":"Jaffe R","year":"2008"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPH.0000000000000196"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2006.00403.x"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2061"},{"key":"e_1_2_4_6_1","first-page":"1358","article-title":"Multiple primary cancer","volume":"16","author":"Warren S","year":"1932","journal-title":"Am J Cancer"},{"key":"e_1_2_4_7_1","first-page":"81","article-title":"Seven different primary cancers in a single patient. 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