{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T12:13:11Z","timestamp":1762431191834},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T00:00:00Z","timestamp":1478476800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>Lymphoepithelioma\u2010like carcinoma (LELC) is a rare neoplasm of the cervix. The importance of distinguishing this undifferentiated carcinoma with a predominant lymphocytic infiltrate lies in the fact that despite being poorly differentiated they have a better prognosis. The diagnosis however becomes more challenging when the pathologist is provided with a small cervical biopsy or a Papanicolaou smear. While the reports describing histology and their relation to Epstein\u2013Barr virus (EBV) are many, there are only few case reports describing the cytology of these tumors. We describe the cytological features of LELC of cervix on conventional smear and correlate it with the histopathological findings of the same. A 67\u2010year\u2010old multiparous Hindu woman presented to the gynecology outpatient department with the history of postmenopausal bleeding for the past six months. The cytological examination of the cervical smear (Papanicolaou stain) was done followed by cervical and endometrial biopsy. Based on Papanicolaou smear and biopsy suggestive of a poorly differentiated carcinoma a radical hysterectomy with pelvic lymphadenectomy was performed. Hysterectomy specimen showed the morphology of LELC and was then correlated with the cervical smears retrospectively. On review of cytological smears it was seen that the tumor cell clusters had an abundant lymphoid background, which was overlooked earlier. Immunohistochemistry for EBV was negative. We conclude that the presence of undifferentiated tumor cell clusters with ill\u2010defined cell borders and large number of lymphoid cells in the background suggest the diagnosis of LELC on cervical cytology.  Diagn. Cytopathol. 2017;45:239\u2013242. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23629","type":"journal-article","created":{"date-parts":[[2016,11,7]],"date-time":"2016-11-07T06:39:18Z","timestamp":1478500758000},"page":"239-242","source":"Crossref","is-referenced-by-count":12,"title":["Lymphoepithelioma\u2010like carcinoma of cervix"],"prefix":"10.1002","volume":"45","author":[{"given":"Ruchi","family":"Rathore","sequence":"first","affiliation":[{"name":"Department of Pathology University College of Medical Sciences Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinod K.","family":"Arora","sequence":"additional","affiliation":[{"name":"Department of Pathology University College of Medical Sciences Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bharat","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology University College of Medical Sciences Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,7]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328488"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330995"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2005.01.016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19970701)80:1<91::AID-CNCR12>3.0.CO;2-A"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e31818fb0a9"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/hupa.2001.20901"},{"key":"e_1_2_6_8_1","first-page":"787","article-title":"Medullary carcinoma with lymphoid infiltration of the uterine cervix\u2014Pathological picture of a case of cervix cancer with a favorable prognosis","volume":"14","author":"Hamazaki M","year":"1968","journal-title":"Gan No Rinsho"},{"key":"e_1_2_6_9_1","first-page":"829","article-title":"Carcinoma of the uterine cervix resembling lymphoepithelioma","volume":"66","author":"Hafiz MA","year":"1985","journal-title":"Obstet Gynecol"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197605)37:5<2238::AID-CNCR2820370513>3.0.CO;2-D"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9378(86)90652-6"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23629","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23629","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23629","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:14:13Z","timestamp":1696551253000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23629"}},"subtitle":["Cytological Features on Conventional Cervical Smear"],"short-title":[],"issued":{"date-parts":[[2016,11,7]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/dc.23629"],"URL":"https:\/\/doi.org\/10.1002\/dc.23629","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,7]]}}}