{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T17:02:14Z","timestamp":1743526934104},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T00:00:00Z","timestamp":1480118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:p>A small percentage of nodular lymphocytic predominant Hodgkin lymphoma (NLPHL) progresses to diffuse large B\u2010cell lymphoma (DLBCL). There have also been rare reports of gray zone lymphoma with features intermediate between classical Hodgkin lymphoma (CHL) and DLBCL. We report a very rare case of composite lymphoma (CHL and NLPHL) progressing to DLBCL, and highlight the diagnostic difficulty faced during its fine\u2010needle aspiration (FNA) cytology diagnosis. A 65\u2010year\u2010old woman presented with a right axillary swelling which was subjected to FNA cytology. The routine FNA cytology diagnosis was anaplastic large cell lymphoma (ALCL) but immunocytochemistry did not support this diagnosis completely. The histopathological diagnosis of the excised lymph node was NLPHL with progression to DLBCL in our hospital but in a hospital abroad where the patient was treated, the reviewed diagnosis was CHL. The patient had a rapid downhill course with development of terminal pleural effusion and died approximately one year from initial diagnosis.The review of the cyto\u2010histologic material along with additional immunocyto\/histochemical studies and the clinical course of the disease support the diagnosis of a composite lymphoma (CHL and NLPHL) with progression to DLBCL. It is suggested that all the three lesions were clonally related. Diagn. Cytopathol. 2017;45:262\u2013266. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23643","type":"journal-article","created":{"date-parts":[[2016,11,26]],"date-time":"2016-11-26T17:02:48Z","timestamp":1480179768000},"page":"262-266","source":"Crossref","is-referenced-by-count":6,"title":["A case of composite classical and nodular lymphocyte predominant Hodgkin lymphoma with progression to diffuse large B\u2010cell non\u2010Hodgkin lymphoma: Diagnostic difficulty in fine\u2010needle aspiration cytology"],"prefix":"10.1002","volume":"45","author":[{"given":"Dilip K.","family":"Das","sequence":"first","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kuwait University  Kuwait"},{"name":"Cytology Unit, Mubarak Al\u2010Kabeer Hospital  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zafar A.","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Cytology Unit, Mubarak Al\u2010Kabeer Hospital  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam H.","family":"Al\u2010Shama'a","sequence":"additional","affiliation":[{"name":"Cytology Unit, Mubarak Al\u2010Kabeer Hospital  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bency","family":"John","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kuwait University  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdulla M. S.","family":"Alawi","sequence":"additional","affiliation":[{"name":"Histopathology Unit, Mubarak Al\u2010Kabeer Hospital  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thamradeen A.","family":"Junaid","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine Kuwait University  Kuwait"},{"name":"Histopathology Unit, Mubarak Al\u2010Kabeer Hospital  Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,11,26]]},"reference":[{"key":"e_1_2_4_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-02-0626"},{"key":"e_1_2_4_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.21077"},{"key":"e_1_2_4_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-14-332"},{"key":"e_1_2_4_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199910)21:4<240::AID-DC3>3.0.CO;2-Z"},{"key":"e_1_2_4_6_1","doi-asserted-by":"publisher","DOI":"10.1309\/KY8C-LCYN-QHJ6-4C6R"},{"key":"e_1_2_4_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.09.009"},{"key":"e_1_2_4_8_1","doi-asserted-by":"publisher","DOI":"10.3816\/CLM.2009.n.042"},{"key":"e_1_2_4_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/5.suppl_1.S7"},{"key":"e_1_2_4_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.24082"},{"key":"e_1_2_4_11_1","volume-title":"World Health Organization Classification of tumours: Pathology and genetics of tumours of haematopoietic and lymphoid tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_4_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0078812"},{"key":"e_1_2_4_13_1","first-page":"242","article-title":"Cellular origin of nodular lymphocyte\u2010predominant Hodgkin's lymphoma: Immunophenotypic and molecular studies","volume":"36","author":"Chan WC.","year":"1999","journal-title":"Semin Hematol"},{"key":"e_1_2_4_14_1","first-page":"300","article-title":"Nodular lymphocyte\u2010predominant Hodgkin lymphoma or T\u2010cell\/histiocyte rich large B\u2010cell lymphoma: The problem in \u201cGrey Zone\u201d lymphomas","volume":"1","author":"Zhao FX.","year":"2008","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_4_15_1","first-page":"2220","article-title":"Expression status of BCL\u20106 and syndecan\u20101 identifies distinct histogenetic subtypes of Hodgkin's disease","volume":"92","author":"Carbone A","year":"1998","journal-title":"Blood"},{"key":"e_1_2_4_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21064"},{"key":"e_1_2_4_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21186"},{"key":"e_1_2_4_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2012.11.018"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23643","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23643","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,6]],"date-time":"2023-10-06T00:13:58Z","timestamp":1696551238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,11,26]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2017,3]]}},"alternative-id":["10.1002\/dc.23643"],"URL":"https:\/\/doi.org\/10.1002\/dc.23643","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,11,26]]}}}