{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T05:57:29Z","timestamp":1787896649704,"version":"build-2784847793"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T00:00:00Z","timestamp":1485129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Pleural effusion is present in some patients with lung carcinoma. This study was undertaken to evaluate the role of pleural fluid cytology in suspected cases of lung carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this prospective study, 86 cases of suspected primary lung carcinoma associated with pleural effusion were included. Cytomorphology of conventional smears was combined with LBC smears and a cytomorphological diagnosis was offered. An immunopanel of CK7, CK5\/6, p63, TTF1, calretinin, and CD56 was applied on cell blocks. Additional immunochemical markers were performed based on clinical details and cytomorphology, wherever indicated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the patients was 56.8 years. The female to male ratio was 2.1:1. Lung nodule\/mass could be detected in 70.9% cases by CECT chest. Cytomorphology was evaluated in all the 86 cases and IHC was used to refine the cytomorphological diagnosis. After IHC along with clinico\u2010radiological details, 61\/86 (71%) cases were confirmed as metastasis from lung primary, 5\/86 (5.8%) were diagnosed as metastatic adenocarcinoma of extrapulmonary origin, and 6\/86 (7%) were metastatic SCC. A diagnosis of adenosquamous carcinoma was suspected in five cases. Other cases included small cell carcinoma (n\u2009=\u20092), large cell carcinoma (<jats:italic>n<\/jats:italic>\u2009=\u20092), large cell neuroendocrine carcinoma (<jats:italic>n<\/jats:italic>\u2009=\u20093), and mesothelioma (<jats:italic>n<\/jats:italic>\u2009=\u20091). One case remained \u201cuncategorized\u201d even after IHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Immunohistochemistry (IHC) performed on the pleural fluid sample can accurately diagnose and subtype primary lung carcinoma even in cases where radiology failed to identify a definite lung lesion. IHC can further help in delineating primary site in tumors of extrapulmonary origin. \u00a9 2017 Wiley Periodicals, Inc. Diagn. Cytopathol. 2017;45:195\u2013201. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23659","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T13:12:50Z","timestamp":1485177170000},"page":"195-201","source":"Crossref","is-referenced-by-count":8,"title":["Pleural fluid cytology samples in cases of suspected lung cancer: An experience from a tertiary care centre"],"prefix":"10.1002","volume":"45","author":[{"given":"Gurwinder","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raje","family":"Nijhawan","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nalini","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navneet","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arvind","family":"Rajwanshi","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynaecological Pathology Postgraduate Institute of Medical Education and Research Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,23]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"World Health Organization. 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