{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,28]],"date-time":"2026-05-28T03:28:51Z","timestamp":1779938931767,"version":"3.53.1"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T00:00:00Z","timestamp":1485820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,4]]},"abstract":"<jats:p>Blastoid variant (BV) is one of the aggressive variants of mantle cell lymphoma (MCL). BV\u2010MCL is defined by its blastic cytomorphology. Previous studies using sequential biopsies in cases with MCL have demonstrated that classical type MCL (C\u2010MCL) often transforms or relapses as an aggressive variant, but a histopathological transition from C\u2010MCL to an aggressive MCL variant in the same pathological specimen has been shown in only a limited number of the cases. We present a case of MCL in which a histological transition between C\u2010MCL and BV\u2010MCL was observed in the same lymph node. A 53\u2010year\u2010old man presented with a submandibular tumor. Touch imprint cytology revealed a monotonous proliferation of large blastic lymphoid cells. Histology revealed a transition between a large lymphoid cell component and small foci of small\u2010 to medium\u2010sized cell component within the tumor. Both components were CD5(+), CD10(\u2212), CD20(+), cyclin D1(+), and SOX11(+) on immunohistochemistry. Fluorescent in situ hybridization revealed the translocation of IgH\/BCL1 locus. These findings led to a final diagnosis of BV\u2010MCL with coexistent C\u2010MCL. The present case suggests the existence of a pathogenetic pathway of MCL from C\u2010MCL to BV\u2010MCL. Because it is important to accurately identify BV\u2010MCL for prognostication, appropriate ancillary diagnostic tools should be used in suspected cases. Diagn. Cytopathol. 2017;45:364\u2013370. \u00a9 2016 Wiley Periodicals, Inc.<\/jats:p>","DOI":"10.1002\/dc.23672","type":"journal-article","created":{"date-parts":[[2017,1,31]],"date-time":"2017-01-31T13:41:09Z","timestamp":1485870069000},"page":"364-370","source":"Crossref","is-referenced-by-count":4,"title":["Classical type and blastoid variant mantle cell lymphoma in the same lymph node: Histology and cytological findings from a touch imprint specimen"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-8149","authenticated-orcid":false,"given":"Shin\u2010ichi","family":"Nakatsuka","sequence":"first","affiliation":[{"name":"Department of Pathology Kansai Rosai Hospital Amagasaki Hyogo 660\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadasuke","family":"Nagatomo","sequence":"additional","affiliation":[{"name":"Department of Pathology Osaka University Hospital Osaka 565\u20100871 Japan"},{"name":"Department of Clinical Laboratory Kansai Rosai Hospital Amagasaki Hyogo 660\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruaki","family":"Nagano","sequence":"additional","affiliation":[{"name":"Department of Pathology Kansai Rosai Hospital Amagasaki Hyogo 660\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayoshi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Pathology Kansai Rosai Hospital Amagasaki Hyogo 660\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Deparment of Hematology Kansai Rosai Hospital Amagasaki Hyogo 660\u20108511 Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,1,31]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"229","volume-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-1615"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199008000-00007"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402272"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2005.05716.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a059154"},{"key":"e_1_2_5_8_1","first-page":"181","article-title":"Centrocytic lymphoma: a distinct clinicopathologic and immunologic entity. 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