{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T07:10:40Z","timestamp":1763968240252,"version":"3.37.3"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,3,24]],"date-time":"2017-03-24T00:00:00Z","timestamp":1490313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Pontificia Universidad Cat\u00f3lica Madre y Maestra (PUCMM)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>Atypical squamous cells of undetermined significance (ASCUS) and atypical glandular cells (AGC) reflect cellular abnormalities insufficient for clear diagnosis. We used cell pellets obtained from liquid\u2010based cytology (LBC) to prepare cell blocks (CB) and clarify the initial diagnosis of ASCUS and AGC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>A total of 393 CBs with initial diagnosis of ASCUS or AGC were processed. Of those, 305 of the ASCUS and 20 of the AGC had adequate specimens. We compared results of CBs prepared from ASCUS and AGC to determine which had higher frequencies of higher\u2010grade lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A majority of specimens (83%) were adequate for evaluation. Compared with the initial diagnosis, 14% (42\/305) of ASCUS were diagnosed with low\u2010grade squamous intraepithelial lesion (LSIL) in CB, while 10% (2\/20) of AGC were diagnosed with LSIL or adenocarcinoma. No statistical relationship between the initial diagnosis of ASCUS and AGC and results of higher\u2010grade lesions in CB is evident as determined by p value greater than 0.05 (p\u2009=\u20090.228).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CBs prepared from Liqui\u2010PREP cell pellets are, in most cases, assessable and can be useful as an adjunctive test to help clarify the initial diagnosis of ASCUS and AGC. Diagn. Cytopathol. 2017;45:520\u2013525. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23707","type":"journal-article","created":{"date-parts":[[2017,3,25]],"date-time":"2017-03-25T09:26:38Z","timestamp":1490433998000},"page":"520-525","source":"Crossref","is-referenced-by-count":7,"title":["The utility of pap cell block preparations with liqui\u2010PREP\u2122 cell pellets to clarify the cytological diagnosis of atypical squamous cells of undetermined significance and atypical glandular cells"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7626-0349","authenticated-orcid":false,"given":"Nicholas B.","family":"George","sequence":"first","affiliation":[{"name":"Department of Medicine School of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra Santiago Republica Dominicana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jashua Haddad","family":"Baldassari","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra Santiago Republica Dominicana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Digno A.","family":"P\u00e9rez Taveras","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra Santiago Republica Dominicana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Jos\u00e9 Fern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra Santiago Republica Dominicana"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda","family":"Concepci\u00f3n Robledo","sequence":"additional","affiliation":[{"name":"Department of Medicine School of Health Sciences, Pontificia Universidad Cat\u00f3lica Madre y Maestra Santiago Republica Dominicana"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,3,24]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BruniL Barrionuevo\u2010RosasL SerranoB et al. 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