{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T02:42:19Z","timestamp":1781664139327,"version":"3.54.5"},"reference-count":16,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2017,4,23]],"date-time":"2017-04-23T00:00:00Z","timestamp":1492905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,7]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate human papillomavirus (HPV) testing as a primary screening tool, we retrospectively analyzed data comparing (1) HPV testing to the algorithms of the ATHENA Study: (2) cytology alone, (3) cytology with ASCUS triage in women 25\u201329 and (4) cotesting\u2009\u2265\u200930 or (5) cotesting\u2009\u2265\u200925.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively analyzed data from women tested with both cytology and HPV testing from 2010 to 2013. Cumulative risk (CR) for CIN3+ was calculated. Crude and verification bias adjusted (VBA) sensitivity, specificity, predictive values, likelihood ratios, colposcopy rate, and screening test numbers were compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>About 15,173 women (25\u201395, 7.1% &lt;30) had both HPV and cytological testing. Nearly 1,184 (8.4%) had biopsies. About 19.4% had positive cytology, 14.5% had positive HPV. HPV testing unassociated with ASCUS was requested in 40% of women &lt;30, versus 84% \u226530, with similar HPV16\/18 genotyping results (68% vs. 70%). 84 CIN3+ were detected with the following 3\u2010year cumulative risk (CR) (95% confidence interval): HPV+\/ASCUS+, 46% (32\u201366%), HPV+\/NILM 30% (15\u201358%), HPV\u2212\/ASCUS+ 12% (6\u201323%), and HPV\u2212\/NILM 0.8% (0.2\u20133.6%). HPV had higher specificity 57% (54\u201360%) than cotesting \u226530 52% (49\u201355%). HPV sensitivity 78% (69\u201387%), positive 12.3% (9.8\u201315.3%), negative 97 (96\u201398%) predictive values, positive 1.8 (1.6\u20132.1) and negative likelihood ratios 0.6 (0.5\u20100.6), were not significantly different. Cotesting increased colposcopy rate and doubled testing per CIN3+ diagnosed. <jats:bold>Conclusion<\/jats:bold>: While HPV\u2212\/NILM cotesting results are associated with low CIN3+ risk, HPV testing had similar screening performance to cotesting and to cytology alone. Additionally, HPV testing and cytology incur false negatives in nonoverlapping subsets of patients. Diagn. Cytopathol. 2017;45:580\u2013586. \u00a9 2017 Wiley Periodicals, Inc.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23726","type":"journal-article","created":{"date-parts":[[2017,4,24]],"date-time":"2017-04-24T04:39:38Z","timestamp":1493008778000},"page":"580-586","source":"Crossref","is-referenced-by-count":10,"title":["Primary HPV testing verification: A retrospective ad\u2010hoc analysis of screening algorithms on women doubly tested for cytology and HPV"],"prefix":"10.1002","volume":"45","author":[{"given":"Jessica","family":"Tracht","sequence":"first","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Wrenn","sequence":"additional","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isam\u2010Eldin","family":"Eltoum","sequence":"additional","affiliation":[{"name":"Department of Pathology the University of Alabama at Birmingham School of Medicine Birmingham Alabama"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,4,23]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0009584"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.07.024"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9896(199909)189:1<12::AID-PATH431>3.0.CO;2-F"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.11.076"},{"key":"e_1_2_5_7_1","unstructured":"FDA approves first human papillomavirus test for primary cervical cancer screening. FDA approves first human papillomavirus test for primary cervical cancer screening. Medical Devices Advisory Committee Panel Meeting Sponsor Executive Summary P100020\/S008.2014."},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPIB65OWHYYRBF"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0119755"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-015-0038-5"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)62218-7"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0034-98872015000100007"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju153"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21544"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.01087-15"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21570"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23726","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23726","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T15:59:49Z","timestamp":1695571189000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,4,23]]},"references-count":16,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2017,7]]}},"alternative-id":["10.1002\/dc.23726"],"URL":"https:\/\/doi.org\/10.1002\/dc.23726","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,4,23]]}}}