{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:47:51Z","timestamp":1792007271459,"version":"4.4.0"},"reference-count":11,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:00:00Z","timestamp":1496188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>The purpose of the Papanicolaou (Pap) smear is to detect primary squamous lesions of the uterine cervix. Although most successful at detection of squamous lesions, the Pap may also detect metastatic carcinomas, sarcomas, and melanomas. We report two rare cases of myeloid sarcoma (MS) of the uterine cervix identified on screening Pap smears with concurrent confirmatory cervical biopsies. The purpose of our study is to identify and report cytologic features of MS on Pap smears utilizing a liquid\u2010based ThinPrep method, which has not been previously documented in literature. Two Pap smears were identified from the pathology laboratory information system, both with positive cervical biopsy findings of MS. Both women, age 40 and 39, presented with ureteral obstruction, hydronephrosis, and past medical histories significant for acute myeloid leukemia (AML). On imaging, cervical masses were identified, and subsequent work\u2010up with Pap smears and biopsies were performed. Cytologic examination of the ThinPrep Pap smears were negative for squamous intraepithelial lesion. Atypical hematologic cells were seen in the background with irregular nuclear contours, increased nuclear to cytoplasmic ratios, variably prominent nucleoli, and variable amounts of agranular cytoplasm. The biopsy confirmed these findings to represent MS. MS is defined as a tumor mass of myeloblasts or immature myeloid cells occurring in an extramedullary site. This rarely involves the female genital tract, about 50 reported cases. Although very rare, MSs in the setting of a history of AML are able to be identified on liquid\u2010based ThinPrep smears.<\/jats:p>","DOI":"10.1002\/dc.23763","type":"journal-article","created":{"date-parts":[[2017,6,1]],"date-time":"2017-06-01T02:36:46Z","timestamp":1496284606000},"page":"953-957","source":"Crossref","is-referenced-by-count":2,"title":["Myeloid sarcoma identified on liquid\u2010based cervical cytology samples: A report of two cases"],"prefix":"10.1002","volume":"45","author":[{"given":"Jessica S.","family":"Snider","sequence":"first","affiliation":[{"name":"Medical University of South Carolina Department of Pathology and Laboratory Medicine Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yekaterina","family":"Eichel","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Department of Pathology and Laboratory Medicine Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alisa M.","family":"Caudell","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Department of Pathology and Laboratory Medicine Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga S.","family":"Chajewski","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Department of Pathology and Laboratory Medicine Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Yang","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Department of Pathology and Laboratory Medicine Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9797-4527","authenticated-orcid":false,"given":"Kathryn G.","family":"Lindsey","sequence":"additional","affiliation":[{"name":"Medical University of South Carolina Department of Pathology and Laboratory Medicine Charleston South Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,5,31]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The Bethesda System for Reporting Cervical Cytology","author":"Solomon D","year":"2008"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742-6413.117356"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1309\/G13Y360MTXLN7KU9"},{"key":"e_1_2_9_5_1","volume-title":"World Health Organization Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_9_6_1","first-page":"1028","volume-title":"The Art and Science of Cytopathology","author":"DeMay RM.","year":"2012"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19810915)48:6<1426::AID-CNCR2820480626>3.0.CO;2-G"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404491"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2008.05.022"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1309\/H9MM21FPT7YBL3PW"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-009-9291-z"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3109\/01443615.2014.940296"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23763","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23763","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T13:32:39Z","timestamp":1695562359000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23763"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,31]]},"references-count":11,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["10.1002\/dc.23763"],"URL":"https:\/\/doi.org\/10.1002\/dc.23763","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,5,31]]}}}