{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:39:07Z","timestamp":1786977547882,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T00:00:00Z","timestamp":1501718400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To evaluate the histologic correlation and clinical significance of atypical glandular cells (AGC) detected on Pap tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Pap tests interpreted as AGC were retrieved from an institutional cytopathology database. The AGC subcategories according to the Bethesda system 2001 include atypical glandular cells, not otherwise specified (AGC\u2010NOS), atypical endometrial cells (AEM), and atypical endocervical cells (AEC). Clinicopathologic variables were collected from medical records retrospectively, and histologic follow\u2010up diagnoses were correlated with AGC subcategories.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      From January 2009 to December 2014, 741 (0.17%) of 435\u00a0778 cervical smears were interpreted as AGC. Of 713 cases included in the study analysis, the distribution of AGC subcategories was as follows: AGC 15.3%, AEM 59.6%, and AEC 25.1%. Of 508 cases with histologic follow\u2010up results, 33.9% of cases were diagnosed to have clinically significant lesions, which include cervical squamous or glandular neoplasia (1.4% and 10.0%), endometrial neoplasia (21.5%), and other metastatic carcinoma (1.0%). Endometrial neoplasia was the most common significant pathology in women aged \u226540 years (28.4%), whereas cervical glandular neoplasia was the most commonly diagnosed lesion in women aged &lt;40 years (14.5%,\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u20090.001). When considering past histories which could affect the Pap results, IUD use (10.3%) and pregnancy (7.3%) were most frequently documented. Although IUD users showed low prevalence of significant pathology (2.6%), AGC cases related with pregnancy preceded significant pathologic lesions in 14.3%.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The relatively high incidence of significant neoplasia linked to AGC emphasizes the importance of adherence to the AGC management guidelines which recommend early and intensive investigation using multiple testing modalities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.23777","type":"journal-article","created":{"date-parts":[[2017,8,3]],"date-time":"2017-08-03T15:38:57Z","timestamp":1501774737000},"page":"867-872","source":"Crossref","is-referenced-by-count":28,"title":["Clinicopathological significance of atypical glandular cells on cervicovaginal Pap smears"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6829-332X","authenticated-orcid":false,"given":"Mi\u2010Kyung","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoo Kyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung Ran","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Pathology Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Taek","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Cheil General Hospital and Women's Healthcare Center, Dankook University College of Medicine Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20877"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1525-1438.2006.00708.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21254"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.68"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.07.047"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000218705.87329.4a"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10761"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00621.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.16.2114"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2009.05.019"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21724"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1999.5360"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000202401.29145.68"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1309\/HL0B-C7Y6-AC77-ND2U"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2003.08.029"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2009.43.5.453"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2006.09.001"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181c799a3"},{"key":"e_1_2_7_20_1","article-title":"Significance 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