{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:11:18Z","timestamp":1740103878491,"version":"3.37.3"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T00:00:00Z","timestamp":1500595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To evaluate reproducibility of a reporting system for endometrial cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytologic slides from 49 patients, prepared via liquid based cytology, were blindly examined by five cytopathologists of various experience levels, applying a recently introduced reporting system as previously reported. The agreement among cytopathologists was evaluated via Kappa (\u03ba) statistics and the Kendall's Coefficient of Variation (<jats:italic>W<\/jats:italic>); cytologic results were compared with the relevant histologic report.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Substantial agreement among all five raters was found in the benign, ACE\u2010L and malignant categories, fair agreement in inadequate and ACE\u2010H categories, whereas only slight agreement in ACE\u2010U. For the three more experienced cytopathologists, an almost perfect agreement was found in inadequate, benign, and ACE\u2010L categories, substantial agreement in ACE\u2010H and malignant categories and fair agreement in ACE\u2010U category. Overall agreement for all five cytopathologists and for all categories was moderate, whereas it was very high for the three senior raters. Using the Kendall's test, both five cytopathologists (<jats:italic>W<\/jats:italic>\u2009=\u20090.81) and the three senior ones (<jats:italic>W<\/jats:italic>\u2009=\u20090.93) had very high agreement. Sensitivity: 83.33\u201392.59%, specificity: 83.33\u201394.74%, ROC area: 71.72\u201390.3%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Application of appropriate statistical tests shows that integration of a new reporting cytologic system is effective with an overall accuracy around 90%. Both statistical tests applied disclosed lower agreement rates among both all five raters and the three most experienced ones in the intermediate categories constituting the gray zone, thus delineating the need for better training of cytopathologists to correctly identify diagnostic criteria for classification of a given case into these categories.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23787","type":"journal-article","created":{"date-parts":[[2017,7,21]],"date-time":"2017-07-21T14:20:03Z","timestamp":1500646803000},"page":"883-888","source":"Crossref","is-referenced-by-count":5,"title":["Internal quality control in an academic cytopathology laboratory for the introduction of a new reporting system for endometrial cytology"],"prefix":"10.1002","volume":"45","author":[{"given":"Niki","family":"Margari","sequence":"first","affiliation":[{"name":"Department of Cytopathology National and Kapodistrian University of Athens, \u201cAttikon\u201d, University Hospital 1, Rimini street, Haidari GR\u201012462 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0074-3619","authenticated-orcid":false,"given":"Abraham","family":"Pouliakis","sequence":"additional","affiliation":[{"name":"Department of Cytopathology National and Kapodistrian University of Athens, \u201cAttikon\u201d, University Hospital 1, Rimini street, Haidari GR\u201012462 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dionysios","family":"Aninos","sequence":"additional","affiliation":[{"name":"Department of Cytopathology National and Kapodistrian University of Athens, \u201cAttikon\u201d, University Hospital 1, Rimini street, Haidari GR\u201012462 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christos","family":"Meristoudis","sequence":"additional","affiliation":[{"name":"Department of Cytopathology National and Kapodistrian University of Athens, \u201cAttikon\u201d, University Hospital 1, Rimini street, Haidari GR\u201012462 Athens Greece"},{"name":"Institute of Pathology Aalborg University Hospital Ladegardsgade 3 Aalborg 9100 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalini","family":"Stamataki","sequence":"additional","affiliation":[{"name":"Department of Cytopathology National and Kapodistrian University of Athens, \u201cAttikon\u201d, University Hospital 1, Rimini street, Haidari GR\u201012462 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ioannis","family":"Panayiotides","sequence":"additional","affiliation":[{"name":"2nd Department of Pathology National and Kapodistrian University of Athens, \u201cAttikon\u201d, University Hospital 1, Rimini street, Haidari GR\u201012462 Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Petros","family":"Karakitsos","sequence":"additional","affiliation":[{"name":"Department of Cytopathology National and Kapodistrian 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