{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:11:29Z","timestamp":1740103889440,"version":"3.37.3"},"reference-count":18,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2017,7,27]],"date-time":"2017-07-27T00:00:00Z","timestamp":1501113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A 51\u2010year\u2010old female who presented with obstructive jaundice was found to have masses in the pancreatic head and tail as well as suspicious liver and periaortic masses on imaging. Aspiration cytology of the pancreatic tail mass showed abundant large single cells with vacuolated eosinophilic cytoplasm, marked nuclear pleomorphism, large bizarre irregular nuclei, binucleation, and prominent nucleoli. Numerous cells also showed intracytoplasmic black to brown pigmentation. A cell block was obtained and extensive immunohistochemical staining was performed. S\u2010100, HMB\u201045, Sox10, pancytokeratin, CK7, RCC antigen, synaptophysin, HepPar 1, inhibin, CD45, CD21, and CD123 were negative, making melanoma, epithelial malignancies, lymphoma, follicular dendritic and plasmacytoid dendritic cell neoplasms less likely. CD4 and CD56 showed partial positivity, and CD68, CD163, and CD14 were positive, supporting the diagnosis of histiocytic sarcoma. Surgical specimens and immunohistochemistry confirmed the cytologic findings. Histiocytic sarcoma is a rare aggressive malignancy of histiocytic origin with most cases presenting in adults in extranodal sites, most commonly the intestinal tract. Few cases are reported in the literature, presenting diagnostic challenges for cytopathologists when seen on fine\u2010needle aspiration. We present the first reported case of histiocytic sarcoma presenting as a pancreatic mass, diagnosed by endoscopic ultrasound guided fine\u2010needle aspiration (EUS\u2010FNA). This entity is rarely described on cytology and arose in a location in which EUS\u2010FNA is the diagnostic modality of choice. This case study highlights that cytopathologists should be aware of histiocytic sarcoma occurring in extranodal locations accessible by EUS\u2010FNA and be familiar with the cytomorphologic appearance.<\/jats:p>","DOI":"10.1002\/dc.23788","type":"journal-article","created":{"date-parts":[[2017,7,28]],"date-time":"2017-07-28T08:29:23Z","timestamp":1501230563000},"page":"1142-1147","source":"Crossref","is-referenced-by-count":1,"title":["Fine\u2010needle aspiration findings of a rare hematopoietic neoplasm presenting as obstructive jaundice"],"prefix":"10.1002","volume":"45","author":[{"given":"Jessica","family":"Tracht","sequence":"first","affiliation":[{"name":"University of Alabama at Birmingham, Department of Pathology 619 19<sup>th<\/sup> Street South, HSB136, Birmingham Alabama 34249"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali M.","family":"Ahmed","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Division of Gastroenterology and Hepatology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2825-485X","authenticated-orcid":false,"given":"Frida","family":"Rosenblum Donath","sequence":"additional","affiliation":[{"name":"University of Alabama at Birmingham, Department of Pathology 619 19<sup>th<\/sup> Street South, HSB136, Birmingham Alabama 34249"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,27]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"367","volume-title":"WHO Classification of Tumors of Haematopoietic and Lymphoid Tissues","author":"Grogan TMPS","year":"2008"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2002.01418.x"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/107327481402100405"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000131541.95394.23"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1827.2011.02671.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22876"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23285"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1384"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2013.357"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v19.i3.422"},{"key":"e_1_2_6_12_1","first-page":"34","article-title":"[Histiocytic sarcoma of the stomach]","volume":"75","author":"Dolzhikov AA","year":"2013","journal-title":"Arkhiv Patologii."},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21215"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22974"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.151133"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.3960\/jslrt.53.1"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800346"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2015.319"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-016-1965-2"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T06:45:25Z","timestamp":1695537925000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,27]]},"references-count":18,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["10.1002\/dc.23788"],"URL":"https:\/\/doi.org\/10.1002\/dc.23788","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2017,7,27]]}}}