{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:01:23Z","timestamp":1787940083647,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2017,11]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>Fine needle aspiration (FNAB) is an effective, minimally\u2010invasive, inexpensive, diagnostic technique. The objective of this study was to evaluate the accuracy of FNAB in the diagnosis of bone lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>FNABs of bone lesions diagnosed at our institution over a 2\u2010year period were retrospectively analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>241 samples were reviewed. Patients included 121\u00a0males and 120\u00a0females, with ages ranging from 4\u201095\u00a0years (mean\u00a0=\u00a066\u00a0years). Of these 241 cases, 43.2% had FNAB and 56.8% had FNAB with core needle biopsy (CNB). The cytologic diagnoses were categorized as nondiagnostic, benign, atypical, suspicious, and positive for malignant cells. Total of 84.3% of FNABs were diagnostic. Of the malignant cases, 78.5% were metastases from nonosseous primary sites, 17.1% were lymphoproliferative lesions, and 4.4% were primary bone tumors. The most common site of metastasis was the pelvic bones (43.5%) followed by the vertebral column (38.7%). Breast (21%), lung (12.7%), and prostate (11.3%) were the most common identifiable primary site in metastatic cases. FNA smears and cell blocks allowed identification of metastatic lesions in 94.3% cases with immunohistochemistry (IHC). Obtaining a concomitant CNB did not result in a statistically significant increase in overall diagnostic yields (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.20), ascertaining presence of metastatic lesion (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.96) or ability to identify site of primary tumor in cases of metastasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.53) compared to FNAB alone. Diagnostic accuracy was improved by reviewing clinical history, performing cell block, and IHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FNAB is a reliable tool for diagnosis of bone lesions with comparable diagnostic sensitivity to CNB.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23807","type":"journal-article","created":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T13:47:11Z","timestamp":1504273631000},"page":"989-997","source":"Crossref","is-referenced-by-count":14,"title":["Fine\u2010needle aspiration biopsy of lytic bone lesions: An institution's experience"],"prefix":"10.1002","volume":"45","author":[{"given":"Uday","family":"Shergill","sequence":"first","affiliation":[{"name":"Department of Pathology Lenox Hill Hospital\u2010Hofstra Northwell Health School of Medicine, 100 East 77th Street, 12th Floor New York New York 10075"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4220-2829","authenticated-orcid":false,"given":"Taisia","family":"Vitkovski","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hofstra Northwell Health School of Medicine, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Stoffels","sequence":"additional","affiliation":[{"name":"Biostatistics Unit Feinstein Institute for Medical Research, 350 Community Drive Manhasset New York 11030"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Klein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Division of Cytopathology Northwell Health Laboratories, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia","family":"Gimenez","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hofstra Northwell Health School of Medicine, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Laser","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hofstra Northwell Health School of Medicine, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rubina","family":"Cocker","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hofstra Northwell Health School of Medicine, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Chau","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Division of Cytopathology Northwell Health Laboratories, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasturi","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Hofstra Northwell Health School of Medicine, 6 Ohio Drive, Suite 202 Lake Success New York 11042"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(31)90237-7"},{"key":"e_1_2_7_3_1","first-page":"517","article-title":"Further studies on the diagnosis of bone tumors by aspiration biopsy","volume":"80","author":"Snyder RE","year":"1945","journal-title":"Surg 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