{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:50:33Z","timestamp":1783486233178,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T00:00:00Z","timestamp":1506470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,2]]},"abstract":"<jats:p>Papillary thyroid carcinoma (PTC) is by far the most common thyroid malignancy (over 85%) of all the thyroid cancers. It has excellent prognosis and 10\u2010year survival rate in most of the cases (95%). Most of the tumors are indolent and do not recur or metastasize after removal. However, widespread metastases to lung, skeleton, central nervous system and, occasionally, other organs may be observed. In rare instances, this disease may metastasize to the pleura and manifest as a malignant pleural effusion (MPE) and portend poor prognosis. This article reports the cytomorphologic and immunocytochemical findings of a female patient with a symptomatic pleural effusion resulting from PTC metastatic to the pleura. Pleural fluid cytology revealed abundant papillary clusters with relatively nuclear pleomorphism, intranuclear cytoplasmic inclusions and nuclear grooves, small and distinct nucleoli as well as small discrete vacuoles. Psammoma bodies were not seen. Immunocytochemical staining was positive for TGB, EMA, Ber\u2010EP4, CK19, and negative for TTF\u20101. Metastasis of PTC to pleural fluid is extremely rare and diagnosing the disease by cytology is challenging and requires medical expertise as well as knowledge of clinical context and immunocytochemical staining. Additionally, a cytologic diagnosis of MPE due to PTC provides important treatment information and plays an important role in prognosis.<\/jats:p>","DOI":"10.1002\/dc.23824","type":"journal-article","created":{"date-parts":[[2017,9,27]],"date-time":"2017-09-27T07:25:40Z","timestamp":1506497140000},"page":"204-207","source":"Crossref","is-referenced-by-count":9,"title":["Malignant pleural effusion from papillary thyroid carcinoma diagnosed by pleural effusion cytology: A case report"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8059-8935","authenticated-orcid":false,"given":"Konstantinos","family":"Kosmas","sequence":"first","affiliation":[{"name":"Department of Cytopathology General Chest Diseases Hospital of Athens \u201cSOTIRIA,\u201d  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Tsonou","sequence":"additional","affiliation":[{"name":"Department of Cytopathology General Chest Diseases Hospital of Athens \u201cSOTIRIA,\u201d  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Mitropoulou","sequence":"additional","affiliation":[{"name":"Pathology Department \u201cAgia Sofia\u201d Children's Hospital Athens  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eufrosyni","family":"Salemi","sequence":"additional","affiliation":[{"name":"Department of Cytopathology General Chest Diseases Hospital of Athens \u201cSOTIRIA,\u201d  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danai","family":"kazi","sequence":"additional","affiliation":[{"name":"Department of Cytopathology General Chest Diseases Hospital of Athens \u201cSOTIRIA,\u201d  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ageliki","family":"Theofanopoulou","sequence":"additional","affiliation":[{"name":"Department of Cytopathology General Chest Diseases Hospital of Athens \u201cSOTIRIA,\u201d  Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,9,27]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"278","volume-title":"Differential Diagnosis in Cytopathology","author":"Paolo G","year":"2015"},{"key":"e_1_2_7_3_1","first-page":"1162","volume-title":"Diagnostic Cytology and its Histopathologic Bases","author":"Koss LG","year":"2005"},{"key":"e_1_2_7_4_1","first-page":"51","article-title":"Recurrent papillary thyroid carcinoma with pleural metastasis diagnosed by effusion cytology: A report of cases with clinicopathologic correlation","volume":"74","author":"Sakamoto RI","year":"2015","journal-title":"Hawaii J Med Public Health."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.EJ15-0631"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000441647"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/rcr2.46"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199411000-00010"},{"key":"e_1_2_7_9_1","first-page":"331","volume-title":"Diagnostic Immunohistochemistry: Theranostic and Genomic Applications","author":"Dabbs DJ.","year":"2013"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thorsurg.2012.10.004"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2016.05.87"},{"key":"e_1_2_7_12_1","doi-asserted-by":"crossref","first-page":"611","DOI":"10.26719\/2011.17.7.611","article-title":"Etiology of pleural effusion among adults in the State of Qatar: A 1\u2010year hospital\u2010based study","volume":"17","author":"Khan FY","year":"2011","journal-title":"East Mediterr Health J."},{"key":"e_1_2_7_13_1","first-page":"216","article-title":"Mouse Models of Malignant Pleural Effusions","volume":"26","author":"Iliopoulou M","year":"2013","journal-title":"Pneumon."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000345696"},{"key":"e_1_2_7_15_1","first-page":"483","article-title":"Papillary and undifferentiated thyroid carcinoma presenting as a metastatic papillary serouseffusion. 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