{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:09:50Z","timestamp":1740103790937,"version":"3.37.3"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T00:00:00Z","timestamp":1508371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:p>The majority of cystic squamous cell carcinomas (SCCs) of the neck have been shown to be metastatic tumors from tonsillar SCCs associated with high\u2010risk human papillomavirus (HR HPV). Recent studies have demonstrated cytokeratin (CK)7 involvement in the development of HPV positive SCC, but no report has been issued on its simultaneous expression in primary tonsillar and metastatic tumor with cystic change. We present a case of HPV positive tonsillar SCC of a 42\u2010year\u2010old male that initially manifested as a cystic neck mass expressing CK7, CK19, and p16 in primary and metastatic tumors. Immunohistochemical examination revealed diffuse CK19 and p16 expression, and patchy CK7 expression in the solid components of primary and metastatic tumors. However, in cystic components of metastatic tumors the expression of CK7 and CK19 was preserved but p16 expression was absent, which was consistent with immunocytochemical findings of fine\u2010needle aspirates from cystic neck mass. In immunocytochemistry performed on aspirates of a branchial cleft cyst for the comparison of cystic SCC and benign cyst, CK19 staining was positive but CK7 and p16 staining was negative. These results suggest that CK7 immunocytochemistry on aspirated material from cystic neck mass may be a useful adjunct for distinguishing cystic metastasis of tonsillar SCC from branchial cleft cyst, although a larger scale study would be required.<\/jats:p>","DOI":"10.1002\/dc.23841","type":"journal-article","created":{"date-parts":[[2017,10,19]],"date-time":"2017-10-19T10:16:46Z","timestamp":1508408206000},"page":"331-335","source":"Crossref","is-referenced-by-count":1,"title":["Cytokeratin7 expression in histologic and cytologic specimens of cystic neck metastasis from <scp>HPV<\/scp> positive squamous cell carcinoma of the tonsil: A case report"],"prefix":"10.1002","volume":"46","author":[{"given":"Yong Kyun","family":"Cho","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Department of Internal Medicine Gachon University Gil Medical Center Incheon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung Ju","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2014Head and Neck Surgery Nowon Eulji Medical Center, Eulji University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Joo","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of Radiology Nowon Eulji Medical Center, Eulji University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyekyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Daejeon Eulji Medical Center, Eulji University Daejon Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4754-8466","authenticated-orcid":false,"given":"Hojung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Nowon Eulji Medical Center, Eulji University Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,19]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000183"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0095364"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tripleo.2005.08.001"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(19980301)82:5<944::AID-CNCR21>3.0.CO;2-#"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.22464"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-05-0587"},{"key":"e_1_2_6_8_1","first-page":"833","article-title":"Markers of squamocolumnar junction cells in normal tonsils and oropharyngeal cancer with and without HPV infection","volume":"30","author":"Morbini P","year":"2015","journal-title":"Histol Histopathol."},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13027-015-0041-x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-017-0609-4"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-16-0619"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20343"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/039463201002300321"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.76.14.7040-7048.2002"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197401)33:1<228::AID-CNCR2820330134>3.0.CO;2-S"},{"key":"e_1_2_6_16_1","first-page":"98","article-title":"Morphological study of development and functional activity of palatine tonsils in embryonic age","volume":"23","author":"Noussios G","year":"2003","journal-title":"Acta Otorhinolaryngol Ital."},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.07.012"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23841","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:48:20Z","timestamp":1695552500000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23841"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10,19]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/dc.23841"],"URL":"https:\/\/doi.org\/10.1002\/dc.23841","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2017,10,19]]}}}