{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T02:05:46Z","timestamp":1781057146376,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T00:00:00Z","timestamp":1514332800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,6]]},"abstract":"<jats:p>Amyloidosis is a rare condition resulting from extracellular deposition of amyloid, a fibrillary material derived from various precursor proteins. Involvement of the pleura by amyloidosis is a rare but serious complication. Pleural amyloidosis is primarily diagnosed by identifying amyloid deposition by histology on pleural biopsy specimens. Hereby, we report a case of systemic amyloidosis where we were able to identify amyloid in a pleural effusion specimen sent for cytopathology evaluation. A 59\u2010year\u2010old male with newly diagnosed multiple myeloma and systemic amyloidosis underwent therapeutic thoracentesis. The H&amp;E stained cell block sections revealed a single, less than one millimeter focus of waxy material surrounded by a rim of reactive mesothelial cells suspicious for amyloid deposit in a background of fibrin, lymphocytes, and reactive mesothelial cells. The focus stained salmon pink with Congo\u2010red special stain and showed apple\u2010green birefringence under polarized light. Our finding suggests that pleural involvement in patients with systemic amyloidosis can be identified on effusion specimens and avert the need for more invasive procedures like pleural or pulmonary parenchymal biopsies.<\/jats:p>","DOI":"10.1002\/dc.23877","type":"journal-article","created":{"date-parts":[[2017,12,27]],"date-time":"2017-12-27T05:02:36Z","timestamp":1514350956000},"page":"522-524","source":"Crossref","is-referenced-by-count":5,"title":["Amyloidosis diagnosed in cytology specimen of pleural effusion: A case report"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9539-9461","authenticated-orcid":false,"given":"Rashmi","family":"Manur","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Pennsylvania Hospital of the University of Pennsylvania Health System Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ihab","family":"Lamzabi","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Pennsylvania Hospital of the University of Pennsylvania Health System Philadelphia Pennsylvania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,27]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"The Art and Science of Cytopathology","author":"DeMay RM.","year":"1996"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)01274-X"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V79.7.1817.1817"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-61779-551-0_24"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.46.4.324"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.32.5.428"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcp.0000162378.35928.37"},{"key":"e_1_2_5_9_1","first-page":"E112","article-title":"Diagnosis of systemic amyloidosis and amyloidosis mediated cardiomyopathy by VATS pleural biopsy for chronic pleural effusion","volume":"5","author":"Harvey\u2010Taylor J","year":"2013","journal-title":"J Thorac Dis."},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.42.756"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2003.06.007"},{"key":"e_1_2_5_12_1","first-page":"195","article-title":"Pleural amyloidosis imitating pleural malignancy","volume":"20","author":"Coolbear F","year":"2017","journal-title":"Respir Med Case Rep."},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2014.09.001"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1843.2000.00230.x"},{"key":"e_1_2_5_15_1","first-page":"234","article-title":"Pleural effusion in AA amyloidosis\u2014a rare involvement of a rare disease","volume":"23","author":"Dias C","year":"2017","journal-title":"Rev Port Pneumol."},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.2015140179"},{"key":"e_1_2_5_17_1","first-page":"2027","article-title":"Respiratory manifestations in amyloidosis","volume":"118","author":"Xu L","year":"2005","journal-title":"Chin Med J."},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705395"},{"key":"e_1_2_5_19_1","first-page":"624","article-title":"A case of systemic primary amyloidosis with BHL and M protein in pleural effusion","volume":"5","author":"Tsuchiya Y","year":"1993","journal-title":"Jpn J Thorac Dis."},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.02313-2016"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.38.5724"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23877","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,23]],"date-time":"2023-09-23T14:37:18Z","timestamp":1695479838000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23877"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,27]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,6]]}},"alternative-id":["10.1002\/dc.23877"],"URL":"https:\/\/doi.org\/10.1002\/dc.23877","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,27]]}}}