{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T11:45:47Z","timestamp":1783943147905,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,2,19]],"date-time":"2018-02-19T00:00:00Z","timestamp":1518998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>According to the American Society of Colposcopy and Cervical Pathology (ASCCP), a co\u2010test is recommended for patients one year after the detection of non\u2010HPV 16\/18 viral types in association with a negative cervical cytology. In this study, we used immediate colposcopy to evaluate the risks to the patient during the one year waiting period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We included 544 Hpv\u2010positive\/cervical cytology\u2010negative patients who underwent cervical cancer screening from June 2015 to June 2017. Cytological specimens were classified using the Bethesta method on a liquid based preparation. We used the Hybrid Capture 2 system to define HPV DNA. Biopsies were performed on all patients under colposcopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three hundred and seventy\u2010five patients had HPV types 16\/18 and 169 had non\u2010HPV\u201016\/18 oncogenic types. Of the 169 patients who had non\u2010HPV\u201016\/18 oncogenic types, 151 (89%) had no dysplasia, 16 (9.4%) had CIN 1, and 2 (1.1%) had CIN 2\/CIN 3.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>For the patients who had cervical cytology negative\/non\u2010HPV\u201016\/18 positive, we detected that 1.1% of these women had CIN 2\u20103. For this reason, by chasing the algorithm recommended by guidelines, gynecologists take risk missing a diagnosis of CIN 2 plus lesion in 1.1% of patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23905","type":"journal-article","created":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T18:37:35Z","timestamp":1519238255000},"page":"326-330","source":"Crossref","is-referenced-by-count":9,"title":["Immediate biopsy of cervical cytology\u2010negative and non\u2010HPV\u201016\/18 oncogenic types positive patients"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5652-3423","authenticated-orcid":false,"given":"\u0130brahim","family":"Karaca","sequence":"first","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cihan","family":"Comba","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00f6khan","family":"Demirayak","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u0130smail","family":"Alay","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7976-8287","authenticated-orcid":false,"given":"Volkan \u015eakir","family":"Erdo\u011fan","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murat","family":"Ho\u015fg\u00f6ren","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Levent","family":"Ya\u015far","sequence":"additional","affiliation":[{"name":"Bak\u0131rk\u00f6y Dr. Sadi Konuk Education and Reseach Hospital Obstetrics and Gynecology \u0130stanbul TR 34147 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.21955"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2012.06.095"},{"key":"e_1_2_8_4_1","unstructured":"Standpunt minister van VWS screening op baarmoederhalskanker. Available from: www. rivm.nl\/Documenten en publicaties\/Algemeen Actueel\/Uitgaven\/Preventie Ziekte Zorg\/baarmoederhalskankerscreening\/Standpunt minister van VWS screening op baarmoederhalskanker (accessed on January 31 2014)."},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn065"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.461"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/beog.2001.0216"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e318285423c"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182883a34"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1086\/315086"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djn044"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31825c31dd"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(11)70145-0"},{"key":"e_1_2_8_14_1","unstructured":"American Society for Colposcopy and Cervical Pathology HPV genotyping clinical update 2009.http:\/\/www.asccp.org\/consensus.shtmlView In Article"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(10)70230-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"672Y82","DOI":"10.1016\/S1470-2045(09)70156-1","article-title":"HPV testing in combination with liquid\u2010based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial","volume":"10","author":"Kitchener HC","year":"2009","journal-title":"Lancet Oncol."},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2012.11.020"},{"key":"e_1_2_8_18_1","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1093\/jnci\/dji186","article-title":"Human papillomavirus type 16 infections and 2\u2010year absolute risk of cervical precancer in women with equivocal or mild cytologic abnormalities","volume":"2097","author":"Castle PE","year":"2005","journal-title":"J Natl Cancer Inst."},{"key":"e_1_2_8_19_1","first-page":"10","article-title":"HPV DNA positivity in women normal and abnormal cervical smears","volume":"1","author":"Batmaz G","year":"2009","journal-title":"Turk J Gynecol Oncol."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.23333"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2014.15.9.3997"},{"key":"e_1_2_8_22_1","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7314\/APJCP.2013.14.1.511","article-title":"Cost and effectiveness comparison of immediate colposcopy versus human papillomavirus DNA testing in management of atypical squamous cells of undetermined significance in Turkish women","volume":"14","author":"Kececioglu M","year":"2013","journal-title":"Asian Pac J Cancer Prev."}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23905","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23905","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,24]],"date-time":"2023-09-24T10:47:50Z","timestamp":1695552470000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,19]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["10.1002\/dc.23905"],"URL":"https:\/\/doi.org\/10.1002\/dc.23905","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,19]]}}}