{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,4]],"date-time":"2025-05-04T01:14:04Z","timestamp":1746321244734,"version":"3.37.3"},"reference-count":9,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2018,3,23]],"date-time":"2018-03-23T00:00:00Z","timestamp":1521763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,8]]},"abstract":"<jats:p>We report a case of minimal deviation adenocarcinoma (MDA) of the uterine cervix showing varicolored cytopathologic features on Papanicolaou (Pap) smear, which may indicate features suggestive of lobular endocervical glandular hyperplasia (LEGH)\u2010adenocarcinoma sequence. A 57\u2010year\u2010old woman presented with a profuse amount of watery vaginal discharge. Gynecological examination revealed a cervical mass with involvement of the right parametrium. Conventional Pap smear showed hypercellularity consisting of approximately 4 types of clusters as follows: (1) clusters showing a monolayered honeycomb sheet of endocervical cells with golden\u2010yellow mucin and bland nuclei, (2) three\u2010dimensional clusters showing varicolored mucin and irregular nuclear overlapping, (3) irregularly shaped clusters showing distorted chicken\u2010wire\u2010mesh appearance with noticeable protrusions of the nuclei and clear or faint varicolored cytoplasm, and (4) crowded clusters showing scarce mucin and nuclear atypia. The surgically resected uterus revealed LEGH\u2010mimicking lesion with fused papillae and a cribriform pattern in the endocervix and many glands exhibiting gastric differentiation that invaded deeper areas of the stroma with a subtle stromal reaction. Compared with histologic findings, two types of clusters, the crowded cluster with scarce mucin and the cluster with distorted chicken\u2010wire\u2010mesh\u2010type appearance, were considered as adenocarcinoma, and the latter was interpreted as a gastric\u2010type adenocarcinoma. Three\u2010dimensional varicolored type clusters showed atypical features, but insufficient atypical features compared with those of adenocarcinoma. Detection of clusters with varicolored mucin on conventional Pap smear may provide a clue for the early recognition of the malignant potential of LEGH on cytology. The chicken\u2010wire\u2010mesh type clusters may be a characteristic cytologic finding of MDA.<\/jats:p>","DOI":"10.1002\/dc.23932","type":"journal-article","created":{"date-parts":[[2018,3,24]],"date-time":"2018-03-24T00:47:46Z","timestamp":1521852466000},"page":"702-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A case of endocervical minimal deviation adenocarcinoma with varicolored cytopathologic features on Pap smear"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-5490","authenticated-orcid":false,"given":"Makiko","family":"Omori","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Shinohara","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tadao","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Hashi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Yamanashi  Yamanashi 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