{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T21:37:57Z","timestamp":1782769077175,"version":"3.54.5"},"reference-count":19,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T00:00:00Z","timestamp":1543276800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,3]]},"abstract":"<jats:p>Papillary thyroid carcinoma (PTC) is generally associated with an excellent long\u2010term outcome. Distant metastasis is rare with only 5\u20107% of patients developing distant disease. Metastasis of PTC to the pancreas is an exceedingly rare occurrence. To date, few cases have been reported. We present the case of an 81\u2010year\u2010old man with past medical history of PTC status post total thyroidectomy with local recurrence treated with radioactive iodine and selective neck dissection. Ten years after his initial diagnosis, PET\u2010CT scan revealed a new hypermetabolic 1.1 cm \u00d7 0.9 cm left lower lobe lung nodule and hypermetabolism in the proximal body of the pancreas. Follow\u2010up MRI cholangiogram showed a 1.0 \u00d7 0.8 cm T1 hypointense lesion in the proximal body of the pancreas. Endoscopic ultrasound\u2010guided fine\u2010needle aspiration biopsy of the pancreatic mass showed neoplastic epithelial cells arranged in papillary clusters with fibrovascular cores and syncytial sheets with high nuclear to cytoplasmic ratio, visible nucleoli, nuclear pallor, focal nuclear grooves, and rare intranuclear pseudoinclusions. Immunohistochemical stains performed on the smears showed positive nuclear expression of TTF\u20101 and PAX\u20108. The findings were consistent with metastatic PTC. Surgical resection of the lung nodule confirmed metastatic PTC. Pancreatic metastases usually occur after long time intervals with reports of up to 8 years in PTC. This makes the diagnosis more challenging, and metastatic disease should always be in the differential diagnosis in cases presenting with a pancreatic mass, especially in patients with a prior malignancy.<\/jats:p>","DOI":"10.1002\/dc.23954","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T09:07:21Z","timestamp":1543309641000},"page":"214-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Papillary thyroid carcinoma metastatic to the pancreas: Case report"],"prefix":"10.1002","volume":"47","author":[{"given":"Margaret","family":"Cho","sequence":"first","affiliation":[{"name":"NYU School of Medicine, Department of Pathology  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Acosta\u2010Gonzalez","sequence":"additional","affiliation":[{"name":"NYU School of Medicine, Department of Pathology  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-9900","authenticated-orcid":false,"given":"Tamar C.","family":"Brandler","sequence":"additional","affiliation":[{"name":"NYU School of Medicine, Department of Pathology  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-6883","authenticated-orcid":false,"given":"Atreyee","family":"Basu","sequence":"additional","affiliation":[{"name":"NYU School of Medicine, Department of Pathology  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Jun","family":"Wei","sequence":"additional","affiliation":[{"name":"NYU School of Medicine, Department of Pathology  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Simms","sequence":"additional","affiliation":[{"name":"NYU School of Medicine, Department of Pathology  New York New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,27]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30201"},{"key":"e_1_2_6_3_1","unstructured":"National Cancer Institute. Cancer Stat Facts: Thyroid Cancer.http:\/\/seer.cancer.gov\/statfacts\/html\/thyro.html. Accessed July 17 2018."},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000001063"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.185"},{"key":"e_1_2_6_6_1","first-page":"417","article-title":"Pancreatic metastasis of tall cell variant of papillary thyroid carcinoma: diagnosis by endoscopic ultrasound\u2010guided fine needle aspiration","volume":"7","author":"Siddiqui AA","year":"2006","journal-title":"J Pancreas."},{"key":"e_1_2_6_7_1","first-page":"819","article-title":"Pancreatic metastasis of papillary thyroid carcinoma: a case report with review of the literature","volume":"7","author":"Li XO","year":"2014","journal-title":"Int J Clin Exp Pathol."},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2011.0247"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2008.02.010"},{"key":"e_1_2_6_10_1","first-page":"2269","article-title":"Is pancreatic resection justified for metastasis of papillary thyroid cancer?","volume":"26","author":"Meyer A","year":"2006","journal-title":"Anticancer Res."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0026"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9410-7"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0200-RA"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/MPA.0b013e31826c276d"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23114"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21541"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325192"},{"key":"e_1_2_6_18_1","first-page":"1","article-title":"Pancreas as delayed site of metastasis from papillary thyroid carcinoma","volume":"2013","author":"Tunio MA","year":"2013","journal-title":"Case Rep Gastrointest Med."},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP-2017-0001"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.7.2493"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.23954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23954","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.23954","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.23954","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T09:51:32Z","timestamp":1694339492000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.23954"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,27]]},"references-count":19,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["10.1002\/dc.23954"],"URL":"https:\/\/doi.org\/10.1002\/dc.23954","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,27]]},"assertion":[{"value":"2017-12-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-03-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}