{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:14:47Z","timestamp":1760300087666,"version":"3.40.5"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>High\u2010risk human papillomavirus (HPV) test ordering has evolved since the 2006 ASCCP guidelines. In light of the availability of the HPV test results for most women \u226530\u2009y, regardless of the Pap test diagnosis; we examined their value in assessing the overall performance of cytopathologists (CPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data were derived for six CPs for Pap test interpretations over 4 y. HPV positivity rates for atypical squamous cells of undetermined significance (ASC\u2010US) and for patients \u226530\u2009y for negative for intraepithelial lesion or malignancy (NILM) and squamous intraepithelial lesion (SIL) (inclusive of low grade SIL (LSIL), high grade SIL (HSIL), and carcinoma) categories were retrieved for individual CPs. ASC\/SIL ratios were analysed overall and separately for patient groups &lt;30\u2009y and\u2009\u226530\u2009y. Pearson correlation coefficient was calculated to assess correlation between HPV positivity rates for ASC\u2010US, NILM and SIL, and ASC\/SIL ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall ASC\u2010US HPV positivity rate was 41%\u201049% for patients &lt;30\u2009y, 32% for patients \u226530\u2009y. Stratifying by patient age group, ASC\u2010US HPV positivity rate, and ASC\/SIL ratio showed a negative correlation. Excluding an outlier, the NILM HPV positivity rate and ASC\/SIL ratio showed a strong negative correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study shows that ASC\u2010US HPV positivity rate is dependent on the age of the population that is tested. Monitoring of the HPV positivity rates for NILM and SIL categories can serve as an additional objective measure to assess the performance of CPs. Based on the patient population, the laboratory can establish an initial baseline for these rates and use it to adjust interpretive thresholds in ensuring the diagnostic sensitivity of the test and the quality of the interpretation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.23989","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T09:07:06Z","timestamp":1540372026000},"page":"914-918","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["HPV test result monitoring of different Bethesda categories in gynaecologic cytology: A valuable quality assurance measure"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8876-4894","authenticated-orcid":false,"given":"Abha","family":"Goyal","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine New York Presbyterian Hospital\u2010Weill Cornell Medicine  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Street","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan A.","family":"Alperstein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1812-8729","authenticated-orcid":false,"given":"Momin T.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,24]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"7001","article-title":"Clinical laboratory improvement amendments of 1988 final rule","volume":"57","year":"1992","journal-title":"Fed Regist"},{"key":"e_1_2_6_3_1","unstructured":"Cytopathology Laboratory Accreditation Checklist College of American Pathologists Northfield IL.http:\/\/www.cap.org\/ShowProperty?nodePath=\/UCMCon\/ContributionFolders\/WebContent\/pdf\/accreditation-checklists-full-listing.pdf. 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