{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:38:14Z","timestamp":1786977494540,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:00:00Z","timestamp":1540339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The study was undertaken to determine the prevalence of different high risk HPV (HR\u2010HPV) genotypes amongst women residing in Kuwait with epithelial abnormalities in cervical smears and to detect any difference in the distribution of these genotypes between Kuwaiti and Non\u2010Kuwaiti women or between the cytological diagnosis groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Thinprep specimens from women with epithelial abnormalities on cervical smears were subjected to Aptima HR\u2010HPV assay and those found to be HR\u2010HPV positive were genotyped using the Aptima HPV genotyping assay into three groups (i) HPV 16, (ii) HPV 18\/45 and (iii) others.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HR\u2010HPV was found in 229 (30.57%) of the 749 cases with epithelial abnormalities. Of the 116 cases subjected to further genotyping, the non\u201016, 18, 45 genotype accounted for the most prevalent group accounting for 62.93% of the cases, followed by HR\u2010HPV 16 (31.04%) cases and HPV 18\/45 (6.03%) of cases. There was no significant difference between Kuwaiti and non\u2010Kuwaiti women nor was any difference noted between the various cytological diagnosis group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Most HR\u2010HPV infections amongst women residing in Kuwait with epithelial abnormalities are due to HPV types other than the 16, 18 and 45. As HPVs 16 and 18 are considered to be the most prevalent HR\u2010HPV genotypes worldwide, causing invasive cancer, the findings of this study is significant from an epidemiological standpoint. It should also be taken into account before undertaking any HPV vaccination program since the available HPV vaccines protect against HR\u2010HPVs 16 and 18 only.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/dc.24035","type":"journal-article","created":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T06:01:12Z","timestamp":1540360872000},"page":"1036-1039","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Human papillomaviruses other than 16, 18 and 45 are the major high risk HPV genotypes amongst women with abnormal cervical smear cytology residing in Kuwait: Implications for future vaccination strategies"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-4202","authenticated-orcid":false,"given":"Mrinmay K.","family":"Mallik","sequence":"first","affiliation":[{"name":"Cytopathology Unit Mubarak Al Kabeer Hospital  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K.","family":"Das","sequence":"additional","affiliation":[{"name":"Cytopathology Unit Mubarak Al Kabeer Hospital  Kuwait"},{"name":"Department of Pathology, Faculty of Medicine Kuwait University  Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara S.","family":"George","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Kuwait University  Kuwait"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4559-7608","authenticated-orcid":false,"given":"Kusum","family":"Kapila","sequence":"additional","affiliation":[{"name":"Cytopathology Unit Mubarak Al Kabeer Hospital  Kuwait"},{"name":"Department of Pathology, Faculty of Medicine Kuwait University  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