{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T02:10:23Z","timestamp":1740103823422,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T00:00:00Z","timestamp":1535155200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Basic Science Research Program"},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea (NRF)","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Ministry of Science, ICT & Future Planning","award":["NRF-2015R1C1A1A01055032"],"award-info":[{"award-number":["NRF-2015R1C1A1A01055032"]}]},{"name":"The Korean Society for Cytopathologists","award":["2014-02"],"award-info":[{"award-number":["2014-02"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Although the Papanicolaou (Pap) test is the first\u2010line screening method for cervical cancer, it has low sensitivity for detection of human papillomavirus (HPV)\u2010infected cervical lesion compared to the HPV test. The aims of this study are to determine novel cytomorphologic parameters for HPV infection in patients previously diagnosed as negative for intraepithelial lesion or malignancy (NILM) and to comparatively analyze the detection performance of 3 HPV tests: nested PCR, the DNA Chip test, and the Liquid Beads Microarray (LBMA) assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 232 patients diagnosed with NILM were enrolled and assessed using 8 cytomorphologic parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six non\u2010classical cytomorphologic features were identified as novel characteristics suggesting HPV infection in patients initially diagnosed with NILM. A combination of these 6 variables showed the best predictive performance for HPV infection (area under the curve, 0.722). In terms of diagnostic ability, the LBMA assay showed better performance in detection of HPV infection (39.7%) in NILM cases compared to the other tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results suggest that the novel cytomorphologic features used in this study can be used as supportive morphologic parameters to increase the sensitivity of cytological screening tests. The LBMA assay could be used as an advanced method for HPV detection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24049","type":"journal-article","created":{"date-parts":[[2018,8,25]],"date-time":"2018-08-25T12:04:18Z","timestamp":1535198658000},"page":"833-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Novel cytomorphologic characteristics suggesting human papillomavirus infection in patients diagnosed as negative for intraepithelial lesion or malignancy and a comparison of diagnostic performance of three human papillomavirus tests"],"prefix":"10.1002","volume":"46","author":[{"given":"Min\u2010Sun","family":"Jin","sequence":"first","affiliation":[{"name":"Department of Pathology Bucheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea  Bucheon Gyeonggi\u2010do South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyebin","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min A.","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In Ae","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chul","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyoung Jin","family":"An","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobae","family":"Shim","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hye","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Kyung","family":"Won","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2508-9796","authenticated-orcid":false,"given":"Han Suk","family":"Ryu","sequence":"additional","affiliation":[{"name":"Department of Pathology Seoul National University Hospital, Seoul National University College of Medicine  Seoul South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,8,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMp058171"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa071430"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2013.10.003"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21139"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0058678"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2004.00179.x"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22842"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20698"},{"key":"e_1_2_6_10_1","first-page":"F55","article-title":"Papillomavirus infections\u2010a major cause of human cancers","volume":"1288","author":"zur Hausen H","year":"1996","journal-title":"Biochim Biophys Acta"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60022-7"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000430081"},{"key":"e_1_2_6_13_1","unstructured":"GeneFinder. 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