{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T01:38:12Z","timestamp":1788917892127,"version":"build-2803163510"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2018,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Adenoid cystic carcinoma (ACC) arises at sites where seromucinous or sweat gland epithelium is present and commonly affects the salivary glands. Rarely it can occur at extra\u2010salivary locations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of 19 cases of ACC diagnosed on fine needle aspiration cytology (FNAC) over a period of 15\u2009y (2002\u20102016) was made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 19 total cases, there were 10 salivary and 9 extra\u2010salivary ACCs. Extra\u2010salivary tumours were seen in 2 cases each in trachea, tongue and in one case each in bronchus, lung, subcutaneous tissue, maxillary antrum, and external auditory canal. The age ranged from 14\u201080\u2009y (mean: 49.5\u2009y), 10 patients were male and 9 were female. The smears were highly cellular in 11 cases, moderately cellular in 5 cases while 3 cases were paucicellular. Multilayered dense clusters, tissue fragments, dispersed cells and cup\u2010shaped fragments were seen. Relatively uniform cells with high nuclear: cytoplasmic ratio, hyperchromatic nuclei, irregular margins, and nuclear moulding were observed. Variable sized hyaline globules, finger\u2010like hyaline material, hyaline cylinders, and hyaline cords were noted. The cytologic diagnosis of ACC was rendered in 13 cases while in 6 cases it was one of the differential diagnosis including monomorphic adenoma, membranous variant of basal cell adenoma, adnexal tumour, polymorphous adenocarcinoma, and pleomorphic adenoma (PA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Cytologists must be aware of varied locations where ACC can occur. A diagnosis of ACC must not rely exclusively on the occurrence of hyaline globules but necessitates a close scrutiny of cellular and nuclear features to avoid diagnostic pitfalls.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24075","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T18:54:46Z","timestamp":1538765686000},"page":"1004-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Adenoid cystic carcinoma: A study of 19 cases of salivary and extra\u2010salivary tumours diagnosed by fine needle aspiration cytology"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2541-4379","authenticated-orcid":false,"given":"Reetu","family":"Kundu","sequence":"first","affiliation":[{"name":"Department of Pathology Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1272-6955","authenticated-orcid":false,"given":"Uma","family":"Handa","sequence":"additional","affiliation":[{"name":"Department of Pathology Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajpal Singh","family":"Punia","sequence":"additional","affiliation":[{"name":"Department of Pathology Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arjun","family":"Dass","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varinder","family":"Saini","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine Government Medical College and Hospital  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1007\/BF02911012","article-title":"Adenoid cystic carcinoma \u2010 clinical presentation and cytological diagnosis","volume":"54","author":"Dutta NN","year":"2002","journal-title":"Indian J Otolaryngol Head Neck Surg."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20500"},{"key":"e_1_2_6_4_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.5005\/ijcdas-56-3-175","article-title":"A rare case of primary adenoid cystic carcinoma of lung","volume":"56","author":"Mukherjee S","year":"2014","journal-title":"Indian J Chest Dis Allied Sci."},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-014-0755-x"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326608"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20015"},{"key":"e_1_2_6_8_1","first-page":"S100","article-title":"Review of fine\u2010needle aspiration cytology of salivary gland neoplasms, with emphasis on differential diagnosis","volume":"118","author":"Mukunyadzi P","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.5858\/2005-129-26-PISGFC"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.70748"},{"key":"e_1_2_6_11_1","first-page":"59","article-title":"Aspiration biopsy of salivary gland tumors. 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