{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T16:09:54Z","timestamp":1778861394460,"version":"3.51.4"},"reference-count":44,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T00:00:00Z","timestamp":1546473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Anal intraepithelial neoplasia (AIN) refers to a precancerous lesion of anal squamous cell carcinoma (SCC). Human papillomavirus (HPV) is considered a crucial risk factor for AIN. Individuals with high\u2010risk sexual behaviour, such as receptive anal intercourse and multiple sexual partners, as well as men who have sex with men exhibit a relatively high rate of AIN. The anal cytology is a screening method for AIN in high\u2010risk individuals, and patients with abnormal anal cytology may benefit from high\u2010resolution anoscopy. This study explored the predictive value of the anal cytology for the detection of AIN or worse (AIN+).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We searched the databases of PubMed, BioMed Central, Cochrane Library, and Google Scholar for relevant studies. Studies on the diagnostic efficacy of the anal cytology for predicting anal cancer on a per\u2010patient basis were included. We excluded review articles. Either prospective trials or retrospective studies were included. We performed the meta\u2010analysis by using a random\u2010effects model to generate a pooled sensitivity, specificity, and diagnostic odds ratio (DOR). All analyses were performed using the MetaDiSc version 1.4 software (Universidad Complutense<jats:italic>,<\/jats:italic> Madrid<jats:italic>,<\/jats:italic> Spain).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve studies with 2541 participants were retrieved. The meta\u2010analysis of the studies assessing the predictive value of the anal cytology for detecting AIN+ generated a pooled sensitivity of 0.79 (95% confidence interval [CI], 0.77\u20100.82) and a pooled specificity of 0.66 (95% CI, 0.64\u20100.69). The pooled DOR for the anal cytology was 5.31 (95% CI, 3.31\u20108.49).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results revealed that the anal cytology might be effective in diagnosing AIN+.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24078","type":"journal-article","created":{"date-parts":[[2019,1,3]],"date-time":"2019-01-03T13:34:50Z","timestamp":1546522490000},"page":"307-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Predictive value of the anal cytology for detecting anal intraepithelial neoplasia or worse: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"47","author":[{"given":"Cheng\u2010Chieh","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Shin Kong Wu Ho\u2010Su Memorial Hospital  Taipei Taiwan, Republic of 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