{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T02:45:25Z","timestamp":1783651525714,"version":"3.55.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T00:00:00Z","timestamp":1541980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>We investigated serous effusions occurring during the course of an already known hematologic neoplasia or as a first manifestation of it. We correlated cytology results with flow cytometry results, when available. In the absence of flow cytometry, our correlation was based on clinical follow up information obtained retrospectively. We evaluated our results in relation to the data of the literature and we considered some new suggestions for the improvement of cytology service.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Serous effusions in hematologic patients were retrieved from the files of the Department of Cytology, Laiko Hospital, for a period of 2\u2009years. All patients had enrolled either a previous hematologic history, or a suspicious clinical and imaging status. Seventy\u2010three serous effusions were included. Cytology reports consisting of morphology and immunocytochemistry assessment were correlated to flow cytometry results and, occasionally, to clinical follow\u2010up.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the group of patients with previous history, sensitivity was 82.76%, positive predictive value was 100%, specificity 100%, and negative predictive value was 58.33%. In the group of patients without previous history, sensitivity and positive predictive value were both 91%, whereas specificity and negative predictive value could not be estimated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We provide evidence that the diagnostic accuracy of cytology with the adjunct of immunocytochemistry is high compared to flow cytometry for detecting hematologic malignancies. In order to improve clinical performance, it is suggested that a cytology triage of serous effusions in all patients with hematologic malignancy must be implemented.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24110","type":"journal-article","created":{"date-parts":[[2018,11,12]],"date-time":"2018-11-12T10:05:35Z","timestamp":1542017135000},"page":"404-411","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Diagnostic role of cytology in serous effusions of patients with hematologic malignancies"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-1041","authenticated-orcid":false,"given":"Kyriaki","family":"Savvidou","sequence":"first","affiliation":[{"name":"Department of Cytopathology Laiko Hospital of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aglaia","family":"Dimitrakopoulou","sequence":"additional","affiliation":[{"name":"Flow Cytometry\u2010Immunology Department Laiko Hospital of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolitsa","family":"Kafasi","sequence":"additional","affiliation":[{"name":"Flow Cytometry\u2010Immunology Department Laiko Hospital of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Konstantopoulos","sequence":"additional","affiliation":[{"name":"Hematology Clinic, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore","family":"Vassilakopoulos","sequence":"additional","affiliation":[{"name":"Hematology Clinic, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Angelopoulou","sequence":"additional","affiliation":[{"name":"Hematology Clinic, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina","family":"Siakantaris","sequence":"additional","affiliation":[{"name":"1st Department of Internal Medicine, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Penelope","family":"Korkolopoulou","sequence":"additional","affiliation":[{"name":"Department of Pathology, Laiko Hospital National and Kapodistrian University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiotis","family":"Kanavaros","sequence":"additional","affiliation":[{"name":"Department of Anatomy\u2010 Histology\u2010 Embryology University of Ioannina  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Panagiota","family":"Mikou","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Laiko Hospital of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,12]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20432"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19850815)56:4<905::AID-CNCR2820560435>3.0.CO;2-U"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.125.4.1546"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448325"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.14-3119"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1482.106574"},{"key":"e_1_2_5_8_1","first-page":"119","article-title":"Pleural effusions in non\u2010 Hodgkin\u2019 s lymphoma. A cytomorphologic, cytochemical and immunologic study","volume":"31","author":"Das DK","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21257"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2007.00382.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.5858\/2006-130-1497-LITPAC","article-title":"Lymphomas involving the pleura: a clinicopathologic study of 34 cases diagnosed by pleural biopsy","volume":"130","author":"Vega F","year":"2006","journal-title":"Arch Pathol Lab Med"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327623"},{"key":"e_1_2_5_13_1","first-page":"707","article-title":"Malignant effusions correlate with poorer prognosis in patients with diffuse large B\u2010 cell lymphoma","volume":"143","author":"Chen YP","year":"2015","journal-title":"AJCP"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.02.008"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23106"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.1066"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10307"},{"key":"e_1_2_5_18_1","first-page":"43","article-title":"Clinical utility of flow cytometry in pleural lymphocytosis","volume":"12","author":"Finch CJ","year":"1999","journal-title":"Mod Pathol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2008.056929"},{"key":"e_1_2_5_20_1","unstructured":"WHOClassification of Tumors of Haematopoietic and Lymphoid Tissues 4th ed. Lyon International Agency for Research on Cancer 2008."},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01695972"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1993.11.7.1336"},{"key":"e_1_2_5_24_1","first-page":"71","article-title":"Pleural effusion is associated with poor treatment outcome in stage III small non\u2010cleaved cell lymphoma","volume":"5","author":"Sandlund JT","year":"1991","journal-title":"Leukemia"},{"key":"e_1_2_5_25_1","first-page":"161","article-title":"Importance of flow cytometric analysis of serous effusions in the diagnosis of hematopoietic neoplasms in patients with prior hematopoietic malignancies","volume":"32","author":"Iqbal J","year":"2010","journal-title":"Annal Quant Cytol Histol"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10150"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328526"},{"key":"e_1_2_5_28_1","first-page":"125","article-title":"Flowcytometric analysis and cytopathology of body cavity fluids","volume":"31","author":"Stonesifer KJ","year":"1987","journal-title":"Acta Cytol"},{"key":"e_1_2_5_29_1","doi-asserted-by":"publisher","DOI":"10.1309\/GUHKGAJEJ72CEAL7"},{"key":"e_1_2_5_30_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448389"},{"key":"e_1_2_5_31_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.55.4733"},{"key":"e_1_2_5_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12220"},{"key":"e_1_2_5_33_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.53.1268"},{"key":"e_1_2_5_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21584"},{"key":"e_1_2_5_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199603)14:2<155::AID-DC10>3.0.CO;2-L"},{"key":"e_1_2_5_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199708)17:2<134::AID-DC9>3.0.CO;2-G"},{"key":"e_1_2_5_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2005.00597.x"},{"key":"e_1_2_5_38_1","first-page":"S96","article-title":"A case of peripheral T\u2010cell lymphoma, not otherwise specified in a HCV and HTLV\u2010II\u2010positive patient, diagnosed by abdominal fluid cytology","volume":"7","author":"Ameri MD","year":"2016","journal-title":"J Gastrointest Oncol"},{"key":"e_1_2_5_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327635"},{"key":"e_1_2_5_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/106.3.359"},{"key":"e_1_2_5_41_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326330"},{"key":"e_1_2_5_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2011.00937.x"},{"key":"e_1_2_5_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21246"},{"key":"e_1_2_5_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22013"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.24110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24110","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24110","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24110","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T13:11:48Z","timestamp":1694351508000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24110"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,12]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["10.1002\/dc.24110"],"URL":"https:\/\/doi.org\/10.1002\/dc.24110","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,12]]},"assertion":[{"value":"2018-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-10-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-11-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}