{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T19:52:18Z","timestamp":1773949938419,"version":"3.50.1"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2018,12,26]],"date-time":"2018-12-26T00:00:00Z","timestamp":1545782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:sec><jats:title>Objectives<\/jats:title><jats:p>H\u00fcrthle cell (HC) metaplasia is an important feature of chronic lymphocytic (Hashimoto) thyroiditis (HT). However, it is rarely observed in juvenile form HT. In a study based on fine needle aspiration cytology, the cytomorphological difference between pediatric HT and its adult form was studied, with special attention on HC metaplasia and its pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The frequency of following 12 cytomorphological features in 16 pediatric and 104 adult HT cases were compared: follicular cells, lymphoid cells, HCs, plasma cells, lympho\u2010histiocytic aggregates, epithelioid histiocytes, multinucleated giant cells, fire\u2010flare appearance, colloid, intracytoplasmic lumen (ICL) with or without colloid inclusion, paravacuolar granules, and cyst cells. The age decade distribution of HC metaplasia was analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant difference was observed between pediatric HT and its adult form in respect of HC metaplasia and ICL with colloid inclusion in HC. HC were present in 7 (43.8%) of pediatric and 94 (90.4%) of adult HT cases (<jats:italic>P<\/jats:italic>\u2009=\u20090.00006). 1 (6.3%) pediatric and 35 (33.7%) adult HT cases had ICL with colloid inclusion in HC (<jats:italic>P<\/jats:italic>\u2009=\u20090.03698). As compared to first two decades of life, significantly higher number of cases revealed HC metaplasia in every decade from third decade onwards (<jats:italic>P<\/jats:italic>\u2009=\u20090.01290\u20130.00009); however, the difference in respect of ICL with colloid inclusions attained significance during sixth decade only (<jats:italic>P<\/jats:italic>\u2009=\u20090.00235).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>H\u00fcrthlization, which appears to be survival response, is rare in pediatric HT and becomes more pronounced starting from third decade onwards; significant increase in ICL with colloid inclusion is a much more delayed phenomenon.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24140","type":"journal-article","created":{"date-parts":[[2018,12,27]],"date-time":"2018-12-27T06:44:22Z","timestamp":1545893062000},"page":"475-481","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["H\u00fcrthle cell metaplasia in chronic lymphocytic thyroiditis: Role of age factor and review of literature on its molecular pathogenesis"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8340-9220","authenticated-orcid":false,"given":"Dilip K.","family":"Das","sequence":"first","affiliation":[{"name":"Department of Pathology, Faculty of Medicine Kuwait University and Cytology Unit  Mubarak Al\u2010Kabeer Hospital Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,12,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.5858\/2001-125-1031-DUOILA","article-title":"Diagnostic utility of intracytoplasmic lumen and transgressing vessels in evaluation of Hurthle cell lesions by fine\u2010needle aspiration","volume":"125","author":"Yang YJ","year":"2001","journal-title":"Arch Pathol Lab Med."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920211798120763"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2003.008474"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2005.00267.x"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.1994.4.333"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-06-0171"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-009-9102-2"},{"key":"e_1_2_9_9_1","first-page":"45","article-title":"Autoimmune thyroiditis in childhood","volume":"5","author":"Brown RS","year":"2013","journal-title":"J Clin Res Pediatr Endocrinol."},{"key":"e_1_2_9_10_1","first-page":"336","article-title":"Hashimoto thyroiditis in childhood\u2010review of epidemiology, genetic susceptibility and clinical aspects of the disease","volume":"5","author":"Zdraveska N","year":"2012","journal-title":"Maced J Med Sci."},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6614-3-11"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.86353"},{"key":"e_1_2_9_13_1","first-page":"10","article-title":"Lymphocytic thyroiditis\u2014is cytological grading significant? 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