{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T01:58:09Z","timestamp":1772503089625,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T00:00:00Z","timestamp":1549584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Nuclear protein in testis (<jats:italic>NUT)<\/jats:italic> midline carcinoma (NMC) is a rare and aggressive subset of poorly differentiated squamous cell carcinoma that is defined by t(15,19) and typically presents in the midline structures of the head, neck, and mediastinum. We report two cases of NMC that presented uniquely with malignant pleural and pericardial effusions including one with cardiac tamponade at presentation. The first case is of a 25\u2010year\u2010old male patient who presented with progressive dyspnea associated with palpitations and dizziness on standing, found to have large bilateral pleural effusions. The second case is of a previously healthy 29\u2010year\u2010old male patient who presented with progressive dyspnea, cough with expectoration, and a large right lower neck mass of 3 months onset, and a large left pleural effusion and left lung infiltrate on imaging studies. Both cases showed malignant cells on cytology suggestive of poorly differentiated carcinoma. Subsequent histopathological and immunochemistry studies were consistent with the diagnosis of NMC. Both patients had a rapid decline in status and suffered comorbidities secondary to their carcinoma, inevitably leading to their death. It is important to consider <jats:italic>NUT<\/jats:italic> midline carcinomas can present in a variety of clinical scenarios, and it is important to consider in the differential diagnoses when evaluating malignant effusion cytology. Utilization of ancillary testing with a broad immunostain profile including NUT studies, as well as fluorescent in\u2010situ hydridization (FISH) studies are helpful and necessary in making the appropriate diagnosis.<\/jats:p>","DOI":"10.1002\/dc.24150","type":"journal-article","created":{"date-parts":[[2019,2,8]],"date-time":"2019-02-08T08:05:32Z","timestamp":1549613132000},"page":"594-598","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Midline carcinoma expressing <i>NUT<\/i> in malignant effusion cytology"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2737-3854","authenticated-orcid":false,"given":"Krithika Damodar","family":"Shenoy","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9174-7203","authenticated-orcid":false,"given":"Nicholas","family":"Stanzione","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin E.","family":"Caron","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gregory A.","family":"Fishbein","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fereidoun","family":"Abtin","sequence":"additional","affiliation":[{"name":"Department of Radiology, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gentian","family":"Lluri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Hirschowitz","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, David Geffen School of Medicine University of California  Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,8]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"304","article-title":"BRD4\u2010NUT fusion oncogene: 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