{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:51:30Z","timestamp":1747147890969,"version":"3.40.5"},"reference-count":36,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,27]],"date-time":"2019-03-27T00:00:00Z","timestamp":1553644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Dermatofibrosarcoma protuberans (DFSP) is a low\u2010grade spindle cell tumor of the skin commonly arising on the trunk and extremities which tends to be slow growing yet locally aggressive. DFSPs are associated with a good prognosis when surgical excision with negative margins is achieved. Although local recurrences occur up to 50% of incompletely resected cases, distant metastases are very rare. Here, we report a case of DFSP metastasizing to the right hemithorax diagnosed by an endobronchial ultrasound\u2010guided fine\u2010needle aspiration (FNA) 9 years after initial presentation. The aspirate showed a bland spindle cell proliferation that was morphologically similar to the original skin excision; the storiform pattern was particularly prominent in tumor\u2010tissue fragments in the cellblock. Immunostaining showed strong, diffuse positivity for CD34. Molecular studies demonstrated a characteristic COL1A1\/PDGFB fusion in both original and metastatic specimens. A review of the literature revealed that metastatic DFSP most often involves the lungs, occurs usually in cases with fibrosarcomatous transformation and after a local recurrence, and presents on average 4.5 years after the original diagnosis. This case did not show fibrosarcomatous transformation or local recurrence prior to metastasis 9 years later. In summary, it is important to consider the potential for metastases years after a nonrecurring primary DFSP, despite its rarity. Cytologic features when complemented by ancillary studies and awareness of the patient's prior clinical history permit a confident diagnosis of metastatic DFSP by FNA. In addition, by confirming the characteristic translocation, tyrosine\u2010kinase inhibitor imatinib can provide additional treatment options for unresectable metastatic DFSP.<\/jats:p>","DOI":"10.1002\/dc.24179","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T06:55:06Z","timestamp":1553756106000},"page":"797-802","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fine\u2010needle aspiration of dermatofibrosarcoma protuberans metastasizing to hemithorax with superior vena cava compression: Case report and literature review"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0868-692X","authenticated-orcid":false,"given":"Bridget S.","family":"Banach","sequence":"first","affiliation":[{"name":"Department of Pathology The University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatjana","family":"Antic","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia A.","family":"Bridge","sequence":"additional","affiliation":[{"name":"Department of Pathology and Microbiology University of Nebraska Medical Center, The Translational Genomics Research Institute  Phoenix Arizona"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole A.","family":"Cipriani","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Frye","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Medicine The University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas N.","family":"Krausz","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Biernacka","sequence":"additional","affiliation":[{"name":"Department of Pathology The University of Chicago  Chicago Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,27]]},"reference":[{"issue":"3","key":"e_1_2_8_2_1","first-page":"241","article-title":"Dermatofibrosarcoma protuberans: treatment and prognosis","volume":"18","author":"Rutgers EJ","year":"1992","journal-title":"Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg Oncol."},{"issue":"3","key":"e_1_2_8_3_1","first-page":"341","article-title":"Outcomes of surgery for dermatofibrosarcoma protuberans","volume":"30","author":"Chang CK","year":"2004","journal-title":"Eur J Surg Oncol J Eur Soc Surg Oncol Br Assoc Surg 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