{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:52:01Z","timestamp":1773298321082,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T00:00:00Z","timestamp":1553126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>There is a high frequency of human papillomavirus (HPV)\u2010induced lesions in cervix and anus of immunosuppressed patients. However, few studies have evaluated these lesions in kidney\u2010transplanted women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study examined 31 kidney\u2010transplanted women receiving immunosuppressive therapy at the General Hospital of Fortaleza in Brazil. Cervical and anal samples were collected and preserved in order to perform liquid\u2010based cytology and a real\u2010time polymerase chain reaction assay detecting high\u2010risk HPV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients' ages ranged from 31 to 70\u2009years (mean: 42.6\u2009\u00b1\u200910.4). The age of sexual debut varied from 14 to 30\u2009years (mean: 19.7\u2009\u00b1\u20093.8). Cervical cytology was diagnosed as atypical in 25.8% of cases (atypical squamous cells of undetermined significance [ASC\u2010US] in 2 [6.2%], atypical squamous cells, but unable to exclude a high\u2010grade squamous intraepithelial lesion in 1 [3.1%], low\u2010grade squamous intraepithelial lesion [LSIL] in 4 [12.4%], and squamous cell carcinoma in 1 [3.1%]). Anal cytology was atypical in 35.4% of cases (ASC\u2010US in 1 [3.2%] and LSIL in 7 [21.7%]). The presence of cervical HPV was confirmed in 22.5% of patients, and anal HPV was found in 48.8% of the cases. The relative risk of atypical anal cytology in cases of atypical cervical cytology was 4.37 (1.35\u201014.20). High\u2010risk cervical HPV did not significantly increase the risk of having atypical anal cytology. However, for HPV in the anus, this was associated with a relative risk of 10.18 (1.45\u201071.54).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High\u2010risk HPV and atypical cytology are very common in the cervix and anus of kidney\u2010transplanted women. Furthermore, the presence of HPV in an anal sample correlates with an increased risk of atypical anal cytology. HPV tests could be useful tools for identifying patients who require anal cytology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24180","type":"journal-article","created":{"date-parts":[[2019,3,21]],"date-time":"2019-03-21T17:41:43Z","timestamp":1553190103000},"page":"783-787","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prevalence of high\u2010risk HPV and atypia in liquid\u2010based cytology of cervical and intra\u2010anal specimens from kidney\u2010transplanted women"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4617-7269","authenticated-orcid":false,"suffix":"Jr.","given":"Jos\u00e9","family":"Eleut\u00e9rio","sequence":"first","affiliation":[{"name":"Department of Maternal and Child Health, Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Brazil"},{"name":"Division of Molecular Biology Prof. Eleuterio Laboratory  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liana R.","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Department of Maternal and Child Health, Faculty of Medicine Federal University of Cear\u00e1  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana K. S.","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department Federal University of Rio Grande do Norte  Natal Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renata M. N.","family":"Eleut\u00e9rio","sequence":"additional","affiliation":[{"name":"Division of Molecular Biology Prof. Eleuterio Laboratory  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo C.","family":"Giraldo","sequence":"additional","affiliation":[{"name":"Gynecology and Obstetrics Department State University of Campinas  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,21]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"2693681","article-title":"Dual kidney transplantation: a review of past and prospect for future","volume":"2017","author":"Khalil MAM","year":"2017","journal-title":"Int Sch Res Notices"},{"key":"e_1_2_6_3_1","first-page":"e60135","article-title":"It was\/wasn't everything I had imagined: advantages and disadvantages after kidney transplantation","volume":"37","author":"Santos BP","year":"2016","journal-title":"Rev Gaucha Enferm"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200102150-00016"},{"key":"e_1_2_6_5_1","unstructured":"Registro Brasileiro de Transplantes.Dimensionamento dos transplantes no Brasil e em cada estado 2016.http:\/\/www.abto.org.br\/abtov03\/Upload\/file\/RBT\/2016\/RBT2016-leitura.pdf. 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