{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:51:30Z","timestamp":1747147890701,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:p>Sarcomatoid carcinoma is rarely found in pleural or pericardial fluid, with very few cases published to date. Here, we describe a 59\u2010year\u2010old female who presented with cough persisting for 5\u2009months. Chest CT scan revealed a 6.0\u2009cm cavitary mass in the left lung base with bulky mediastinal and hilar lymphadenopathy. An additional 1.2\u2009cm right adrenal mass was seen and was suspicious for metastatic disease. The patient developed dyspnea, tachycardia, pleuritic chest pain and generalized weakness and was admitted to the hospital. She was found to have pleural and pericardial effusions, which were drained and sent to cytology. The fluid revealed enlarged highly pleomorphic malignant cells, some displaying multinucleation with irregular nuclear borders, coarse chromatin and prominent nucleoli. Tumor cells were positive for CK7 and Vimentin and negative for MOC\u201031, Ber\u2010EP4, B72.3, Sox10, Melan\u2010A, TTF\u20101, Napsin\u2010A and CK20. A concurrent surgical biopsy of the tumor mass displayed immunopositivity for AE1\/AE3 and CAM5.2. The tumor was negative for p40, TTF\u20101, calretinin, D2\u201040 and STAT6. A diagnosis of sarcomatoid carcinoma with giant cells and spindle cells was rendered. Sarcomatoid carcinomas of the lung are very uncommon consisting of 1% of non\u2010small\u2010cell lung carcinomas and are even more unusual in cytology specimens. Despite its rarity, it is important to keep this entity in mind in the differential diagnosis of a fluid specimen with bizarre nuclear atypia and the above staining pattern.<\/jats:p>","DOI":"10.1002\/dc.24183","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T18:58:18Z","timestamp":1553540298000},"page":"813-816","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4006-6883","authenticated-orcid":false,"given":"Atreyee","family":"Basu","sequence":"first","affiliation":[{"name":"Department of Pathology NYU School of Medicine  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andre L.","family":"Moreira","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU School of Medicine  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony","family":"Simms","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU School of Medicine  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8272-9900","authenticated-orcid":false,"given":"Tamar C.","family":"Brandler","sequence":"additional","affiliation":[{"name":"Department of Pathology NYU School of Medicine  New York New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cllc.2017.12.008"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4557-3383-5.00054-3"},{"issue":"10","key":"e_1_2_5_4_1","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1684\/bdc.2012.1619","article-title":"Pulmonary sarcomatoid carcinoma","volume":"99","author":"Vieira T","year":"2012","journal-title":"Bull Cancer"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-1-4160-5766-6.00016-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199703)16:3<242::AID-DC10>3.0.CO;2-L"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000333953"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20016"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326198"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21290"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21817"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.4132\/KoreanJPathol.2012.46.6.576"},{"issue":"1","key":"e_1_2_5_13_1","first-page":"72","article-title":"Cytopathologic features of pleomorphic carcinoma of the lung: case report","volume":"28","author":"Dagli AF","year":"2012","journal-title":"Turk Patoloji Derg"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2018.05.016"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1806-37132013000600016"},{"issue":"9","key":"e_1_2_5_16_1","first-page":"688","article-title":"Expression of anaplastic lymphoma kinase fusion gene in patients with lung sarcomatoid carcinoma and treatment analysis","volume":"98","author":"Niu HT","year":"2018","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13505"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2018.07.006"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24183","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24183","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24183","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T01:31:09Z","timestamp":1694309469000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24183"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3,25]]},"references-count":17,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2019,8]]}},"alternative-id":["10.1002\/dc.24183"],"URL":"https:\/\/doi.org\/10.1002\/dc.24183","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2019,3,25]]},"assertion":[{"value":"2018-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}