{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:28:42Z","timestamp":1761989322599,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T00:00:00Z","timestamp":1556064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Solitary fibrous tumor (SFT) is an uncommon fibroblastic neoplasm with considerable risk of local recurrence. SFT is histologically characterized by bland spindled\u2010to\u2010epithelioid cells in alternating hyper\u2010 and hypocellular zones, a \u201cpatternless pattern,\u201d ectatic \u201cstaghorn\u201d vessels with variable edematous perivascular stroma, and thick ropey collagen. Cytologically, smears are variably cellular with spindled\u2010to\u2010epithelioid cells with oval nuclei, wispy cytoplasm, multiple inconspicuous nucleoli, and occasional nuclear pseudoinclusions. Small vessels and bare\/stripped nuclei are generally present while mild atypia is not uncommon. STAT6 nuclear expression is the most useful immunohistochemical stain and is the product of a <jats:italic>NAB2\u2010STAT6<\/jats:italic> gene fusion. SFTs with mediastinal involvement may be diagnostically challenging due to proximity to vital structures and anticipated patient risks. Endobronchial and endoscopic ultrasound\u2010guided fine\u2010needle aspiration (EBUS\/EUS\u2010FNA) are minimally\u2010invasive tissue sampling methods that provide diagnostic material while minimizing patient risk, and the mediastinum is accessible by both procedures. Small aspirate samples and SFT nonspecific features can compound the diagnostic difficulty, although familiarity with the cytologic, morphologic, immunophenotypic, and genetic features of SFTs assist the pathologist in confirming the diagnosis. Pathologists must also be aware of high\u2010risk SFT features to ensure appropriate therapy and management. Case #1 describes a recurrent mediastinal SFT with high\u2010risk features sampled by EUS\u2010FNA. Case #2 describes a primary diagnosis of mediastinal SFT with malignant behavior made on an EBUS\u2010FNA specimen.<\/jats:p>","DOI":"10.1002\/dc.24192","type":"journal-article","created":{"date-parts":[[2019,4,24]],"date-time":"2019-04-24T08:29:24Z","timestamp":1556094564000},"page":"821-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytomorphologic features of malignant solitary fibrous tumor with mediastinal involvement sampled by endoscopic and endobronchial ultrasound\u2010guided fine\u2010needle aspiration: A comparison of two cases"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2861-7585","authenticated-orcid":false,"given":"Meghan","family":"Hupp","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mufaddal","family":"Najmuddin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huseyin Erhan","family":"Dincer","sequence":"additional","affiliation":[{"name":"Department of Pulmonary, Critical Care and Sleep Medicine University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James Shawn","family":"Mallery","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Nutrition University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid","family":"Amin","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"III","given":"Jimmie","family":"Stewart","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine and Pathology University of Minnesota  Minneapolis Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,4,24]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.16.16662"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.12659\/AJCR.903680"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20611"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2010.07.031"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/atm.ATM_340_17"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.14309\/crj.2017.35"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198908000-00003"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199709)17:3<167::AID-DC1>3.0.CO;2-C"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/110.1.50"},{"issue":"3","key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/S0022-5223(19)41262-2","article-title":"Localized mesothelioma of the pleura: benign and malignant variants","volume":"75","author":"Okike N","year":"1978","journal-title":"J Thorac Cardiovasc Surg"},{"key":"e_1_2_6_12_1","unstructured":"Surveillance Epidemiology and End Results (SEER) Program (www.seer.cancer.gov\/seerstat) version 8.3.5. 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