{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:40:40Z","timestamp":1778895640211,"version":"3.51.4"},"reference-count":23,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T00:00:00Z","timestamp":1556582400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The objective of this study was to evaluate the accuracy of fine needle aspiration cytology (FNAC) of axillary lymph nodes (LN) in breast cancer, to compare the results of FNAC and pathological examination, and to distinguish patients with 1 to 2 metastatic LNs from those with \u22653 metastatic LNs in patients with FNAC\u2010positive patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>This study included 198 breasts of 196 patients with breast cancer who underwent FNAC and surgery for the primary and axilla without neoadjuvant chemotherapy from January 2010 to August 2016. Axillary nodal status was assessed by ultrasound (US), and whether FNAC\u2010positive had three or more suspicious LNs on US imaging was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results of FNAC were positive in 75 (38%), negative in 97 (49%), suspicious in 2 (1%), indeterminate in 5 (2.5%), and insufficient in 19 patients (9.5%). FNAC sensitivity, specificity, positive predictive value, and negative predictive value were 62.6%, 100%, 100%, and 62.0%, respectively. Whereas 53% (18\/34) of patients with false\u2010negative FNAC had one metastatic LN on final pathology, 61% (47\/77) patients who were FNAC\u2010positive had three or more metastatic LNs. In the FNAC\u2010positive patients, all patients had \u22653 metastatic LNs if they had \u22653 suspicious LNs on US imaging.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with positive cytology were more likely to have \u22653 positive LNs compared to false\u2010negative cytology patients. Patients with \u22653 abnormal LNs on US and positive FNAC might require axillary dissection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/dc.24203","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T05:40:44Z","timestamp":1556689244000},"page":"788-792","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Ultrasound\u2010guided fine\u2010needle aspiration of axillary lymph nodes in breast cancer: Diagnostic accuracy and role in surgical management"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1406-0760","authenticated-orcid":false,"given":"Naoko","family":"Iwamoto","sequence":"first","affiliation":[{"name":"Department of Breast Surgery Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital  Tokyo 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