{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T11:35:26Z","timestamp":1761824126779,"version":"3.40.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T00:00:00Z","timestamp":1557792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The patient is a 72\u2010year\u2010old female who presents with new onset jaundice. The patient has a past medical history significant for right\u2010sided estrogen receptor (ER)\u2010positive and left\u2010sided ER\u2010negative breast cancers in 2005 and 2009, respectively, and recent 1\u2010year history of ER\u2010positive right\u2010sided breast cancer with bone and brain metastases. CT scan and endoscopic ultrasound (EUS) revealed a new 2\u2009cm mass in the head of the pancreas, leading to EUS\u2010guided fine\u2010needle aspiration of the lesion. Pathologic workup revealed adenocarcinoma with signet\u2010ring cells, representing either metastatic breast or primary pancreatic cancer. Immunohistochemistry and molecular diagnostic workup identified positive GATA\u2010binding protein 3 (GATA3) immunoreactivity and a mutation in Erb\u2010B2 receptor tyrosine kinase 2 (ERBB2), also known as human epidermal growth factor receptor 2 (HER2). Here, we review the diagnostic markers commonly used to differentiate metastatic breast vs primary pancreatic adenocarcinoma, and discuss the challenges of utilizing GATA3 immunoreactivity and ERBB2 mutations for diagnosis.<\/jats:p>","DOI":"10.1002\/dc.24210","type":"journal-article","created":{"date-parts":[[2019,5,14]],"date-time":"2019-05-14T15:22:14Z","timestamp":1557847334000},"page":"912-917","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Biomarkers to diagnose metastatic breast carcinoma to the pancreas: A case report and update"],"prefix":"10.1002","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5378-7650","authenticated-orcid":false,"given":"Kevin","family":"Shee","sequence":"first","affiliation":[{"name":"Geisel School of Medicine at Dartmouth  Hanover New 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