{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T05:38:39Z","timestamp":1783575519387,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T00:00:00Z","timestamp":1574812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Very rarely lymphoma primarily or secondarily involves the pancreas. Involvement of the pancreatic parenchyma with lymphoma clinically may mimic pancreatic ductal adenocarcinoma (PDA) and other mass\u2010forming pancreatic lesions. Endoscopic ultrasound fine needle aspiration (EUS\u2010FNA) is the first step in the diagnostic pathway of managing these patients by providing a cytology specimen. Cytologically, lymphoma of pancreas can be misdiagnosed for a wide variety of pancreatic neoplastic and non\u2010neoplastic lesions. Cytological differential diagnosis includes well\u2010differentiated adenocarcinoma, acinar cell carcinoma, well differentiated neuroendocrine tumor, and autoimmune pancreatitis. Gastroenterologist's skills in providing adequate sample for preparing smears, cell blocks and\/or performing flow cytometry, and also cytopathologist's skills in detecting atypical lymphocytic population are crucial factors. Although cytology examination has limitations to subclassify lymphoma, it plays a key role to redirect clinicians into the right patient\u2010care pathway. In this article, we present two cases of pancreatic lymphoma with emphasis on the discriminating cytomorphological features, and we also review literature<jats:styled-content>s<\/jats:styled-content> with reports of primary pancreatic lymphoma (PPL) to better understand the characteristics of this rare lesion.<\/jats:p>","DOI":"10.1002\/dc.24349","type":"journal-article","created":{"date-parts":[[2019,11,27]],"date-time":"2019-11-27T10:59:49Z","timestamp":1574852389000},"page":"350-355","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Pancreatic lymphoma: A cytologic diagnosis challenge"],"prefix":"10.1002","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-3936","authenticated-orcid":false,"given":"Omid","family":"Savari","sequence":"first","affiliation":[{"name":"Department of Pathology, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaynab","family":"Al\u2010Duwal","sequence":"additional","affiliation":[{"name":"Department of Pathology, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santhi","family":"Ganesan","sequence":"additional","affiliation":[{"name":"Department of Pathology, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rania","family":"Danan\u2010Rayes","sequence":"additional","affiliation":[{"name":"Department of Pathology, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salman","family":"Ayub","sequence":"additional","affiliation":[{"name":"Department of Pathology, MetroHealth Medical Center Case Western Reserve University  Cleveland Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1008282818705"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464-001-4247-1"},{"issue":"3","key":"e_1_2_7_4_1","first-page":"262","article-title":"Primary pancreatic lymphomas. JOP","volume":"7","author":"Saif MW","year":"2006","journal-title":"J Pancreas"},{"issue":"5","key":"e_1_2_7_5_1","first-page":"482","article-title":"Primary pancreatic lymphoma or secondary involvement: what is the difference? JOP","volume":"11","author":"Kav T","year":"2010","journal-title":"J Pancreas"},{"issue":"7","key":"e_1_2_7_6_1","first-page":"456","article-title":"Halegoua\u2010DeMarzio D, Loren DE. Primary pancreatic lymphoma presenting as acute pancreatitis","volume":"12","author":"Shnitser A","year":"2016","journal-title":"Gastroenterol Hepatol"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199409000-00019"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.18004921319"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/UAD9PYFUA82X9R9U"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20488"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v12.i31.5064"},{"key":"e_1_2_7_12_1","first-page":"5952315","article-title":"Primary pancreatic Burkitt's lymphoma: a case report and review of the literature","volume":"2018","author":"Konjeti VR","year":"2018","journal-title":"Case Rep Gastrointest Med"},{"issue":"3","key":"e_1_2_7_13_1","first-page":"359","article-title":"Primary follicular lymphoma of the pancreas: a rare tumour mimicking pancreatic carcinoma","volume":"40","author":"Sallapan S","year":"2018","journal-title":"Malays J Pathol"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-6-117"},{"issue":"2","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.15403\/jgld.2014.1121.242.hdk","article-title":"A case of primary pancreatic non\u2010Hodgkin B\u2010cell lymphoma mimicking autoimmune pancreatitis","volume":"24","author":"Anderloni A","year":"2015","journal-title":"J Gastrointestin Liver Dis"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199609000-00008"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0971-5851.56331"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2006.21.2.123"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V116.21.4150.4150"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3412"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3126\/njc.v1i1.25635"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339968"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24349","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24349","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24349","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:45:16Z","timestamp":1694043916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,27]]},"references-count":21,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/dc.24349"],"URL":"https:\/\/doi.org\/10.1002\/dc.24349","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"value":"8755-1039","type":"print"},{"value":"1097-0339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,27]]},"assertion":[{"value":"2019-10-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-11-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}