{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T20:28:01Z","timestamp":1759091281343,"version":"3.40.5"},"reference-count":12,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T00:00:00Z","timestamp":1577491200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Diagnostic Cytopathology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fine\u2010needle aspiration cytology (FNAC) is a preliminary test for the diagnosis of thyroid lesions. We hereby report a rare case of medullary thyroid carcinoma (MTC) co\u2010existing with Hashimoto's thyroiditis (HT). This case was substantiated with ancillary tests on cytology material to give a novel insight. A 60\u2010year\u2010old female presented clinically with diffuse enlargement of the thyroid, and right\u2010side nodule on ultrasonography. FNAC of the isthmic area showed features of HT, while cytology of right\u2010side nodule displayed sheets of plasmacytoid cells and frequent scattered large bizarre and pleomorphic cells, lymphoglandular bodies and pale eosinophilic material. The differential diagnosis of MTC with co\u2010existent HT or high\u2010grade lymphoma was considered. To establish the diagnosis, serum calcitonin and ancillary studies on aspirated material were carried out. High serum calcitonin (7251\u2009pg\/mL), Congophilia on smears, and CD 45\u2212ve; CD56+ve expression of tumor cells on flowcytometric analysis established the diagnosis of MTC over lymphoma. This diagnosis was further confirmed upon histopathology. Ancillary studies on aspirated material established the diagnosis of MTC and excluded the diagnosis of lymphoma. Establishing the correct diagnosis was cardinal in such a scenario as these diseases have extremely diverse management.<\/jats:p>","DOI":"10.1002\/dc.24373","type":"journal-article","created":{"date-parts":[[2019,12,28]],"date-time":"2019-12-28T12:55:00Z","timestamp":1577537700000},"page":"386-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Medullary thyroid carcinoma co\u2010existent with Hashimoto's thyroiditis diagnosed by a comprehensive cytological approach"],"prefix":"10.1002","volume":"48","author":[{"given":"Sheetal","family":"Malpani","sequence":"first","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6360-3592","authenticated-orcid":false,"given":"Ashwani","family":"Tandon","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hemlata","family":"Panwar","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3913-7111","authenticated-orcid":false,"given":"Ujjawal","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neelkamal","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Lab Medicine All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganakalyan","family":"Behera","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vikas","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology All India Institute of Medical Sciences  Bhopal India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,12,28]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00053"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-014-0363-2"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1955.01270080137023"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/80.4.534"},{"key":"e_1_2_7_6_1","first-page":"217","article-title":"Chronic inflammation and cancer","volume":"16","author":"Shacter E","year":"2002","journal-title":"Oncology"},{"key":"e_1_2_7_7_1","first-page":"528","article-title":"Hashimoto's thyroiditis with medullary carcinoma","volume":"35","author":"Gaskin D","year":"1992","journal-title":"Can J Surg"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328285"},{"key":"e_1_2_7_9_1","first-page":"125","volume-title":"Fine Needle Aspiration Cytology","author":"Orell SR","year":"2005"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.130710"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9392-5"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem-39-3-487"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1309\/FU3FDKYN8AU0891N"}],"container-title":["Diagnostic Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fdc.24373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24373","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/dc.24373","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/dc.24373","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:45:07Z","timestamp":1694043907000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/dc.24373"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,28]]},"references-count":12,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,4]]}},"alternative-id":["10.1002\/dc.24373"],"URL":"https:\/\/doi.org\/10.1002\/dc.24373","archive":["Portico"],"relation":{},"ISSN":["8755-1039","1097-0339"],"issn-type":[{"type":"print","value":"8755-1039"},{"type":"electronic","value":"1097-0339"}],"subject":[],"published":{"date-parts":[[2019,12,28]]},"assertion":[{"value":"2019-09-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-28","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}